Abstract
In Niger as in other countries in sub-Saharan Africa malaria represents a major public-health problem. The disease is an important cause of morbidity and mortality particularly among infants and young children. Plasmodium falciparum is the main species involved. Although antimalarial drugs remain an essential component of the global malaria-control strategy resistance of P. falciparum to such drugs is becoming ever more wide-spread and making the choice of treatment difficult in many endemic areas (Wongsrichanalai et al. 2002). For the native population of Niger chloroquine (CQ) remains the recommended first-line treatment for acute uncomplicated P. falciparum malaria although there have been no recent surveys of this drugs efficacy in the country. In the present prospective study the therapeutic efficacy of CQ was assessed among children from the capital city of Niamey. (excerpt)
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