Abstract
RATIONALE: To clarify the role of CPT in children with asthma exacerbations.METHODS: A randomized prospective study with inclusion criteria: diagnosis of asthma by NIH Guidlines definition; age 4-18 years; and hospitalization for status asthmaticus. Exclusion criteria: Co-existing pulmonary or neuromuscular diseases. Following informed consent, pts classified as mild or mod/severe asthmatics by questionnaire are randomized to (+CPT) or (−CPT) group. All received standard therapy for asthma. Airway resistance(AR) by oscillometry(IOS) is measured at t=0 and t=24hrs. The +CPT group receives 6 CPT sessions by respiratory therapist q4 hrs for 24-hrs. Mean changes in AR analyzed by unpaired t-test.RESULTS: Twenty-one pts, 10 male and 11 female were randomized, 11 to (+CPT) and 10 to (−CPT) group. Twelve pts were mild and 9 were mod/severe asthmatics. Mean change in AR for the +CPT was +0.28 and the −CPT group was −0.311 (p=0.23). In mild asthmatics, a strong trend was observed with differences in mean AR of +0.01 for +CPT and −0.765 for the −CPT group (p=0.076). Females showed a significant mean increase in AR for +CPT of +0.88. A decrease in AR of −0.53 in the −CPT group was observed (p=0.03).CONCLUSIONS: Results suggest that pts receiving CPT in asthma exacerbations have increases in AR while pts who do not recieve CPT display decreases. These differences were more pronounced in mild asthmatics. Females receiving CPT have a statistically significant increase in AR compared to a decrease in AR of those without CPT. RATIONALE: To clarify the role of CPT in children with asthma exacerbations. METHODS: A randomized prospective study with inclusion criteria: diagnosis of asthma by NIH Guidlines definition; age 4-18 years; and hospitalization for status asthmaticus. Exclusion criteria: Co-existing pulmonary or neuromuscular diseases. Following informed consent, pts classified as mild or mod/severe asthmatics by questionnaire are randomized to (+CPT) or (−CPT) group. All received standard therapy for asthma. Airway resistance(AR) by oscillometry(IOS) is measured at t=0 and t=24hrs. The +CPT group receives 6 CPT sessions by respiratory therapist q4 hrs for 24-hrs. Mean changes in AR analyzed by unpaired t-test. RESULTS: Twenty-one pts, 10 male and 11 female were randomized, 11 to (+CPT) and 10 to (−CPT) group. Twelve pts were mild and 9 were mod/severe asthmatics. Mean change in AR for the +CPT was +0.28 and the −CPT group was −0.311 (p=0.23). In mild asthmatics, a strong trend was observed with differences in mean AR of +0.01 for +CPT and −0.765 for the −CPT group (p=0.076). Females showed a significant mean increase in AR for +CPT of +0.88. A decrease in AR of −0.53 in the −CPT group was observed (p=0.03). CONCLUSIONS: Results suggest that pts receiving CPT in asthma exacerbations have increases in AR while pts who do not recieve CPT display decreases. These differences were more pronounced in mild asthmatics. Females receiving CPT have a statistically significant increase in AR compared to a decrease in AR of those without CPT.
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