Abstract
C-reactive protein (CRP) is encoded by CRP or PTX1 gene and procalcitonin (PCT) is produced by the CALC-1 gene induction. Both PCT and CRP are known as valued biomarkers markers in prediction of Serious Bacterial Infections (SBI) in children. This experiment carried out to analyze the efficacy of cefotaxime combined with gamma globulins on neonatal sepsis and the effect on CRP and PCT. For this purpose, a total of 120 sepsis children were selected and randomly divided into observation and control groups. Children in the control group were treated with cefotaxime, while children in the observation group were treated with cefotaxime combined with gamma globulins. The two groups were compared in terms of the relative measures of efficacy, the total effective rate of treatment, the incidence of complications and serum CRP and PCT levels before and after treatment. The clinical measures of the observation group were all lower than those of the control group, and the total effective rate of the treatment was higher than that of the control group, while the incidence of complications was lower than that of the control group. In addition, before treatment, there was no difference in CRP and PCT between the two groups; after treatment, the above measures in the observation group were lower than those in the control group. It is concluded that Cefotaxime combined with gamma globulins in the treatment of neonatal sepsis has significant efficacy and is clinically more effective than cefotaxime monotherapy. This combination can shorten clinical symptom remission time and hospital stay, improve serum CRP and PCT levels and promote the recovery of children, worthy of promotion.
Highlights
Children in the control group were treated with cefotaxime, while children in the observation group were treated with cefotaxime combined with gamma globulins
C-reactive protein (CRP) is the name of a protein that is synthesized in the liver in response to factors released from macrophages and fat cells, which in cases of inflammation and rheumatism in the blood increases. procalcitonin (PCT) is a precursor to the hormone calcitonin, which is produced in the C-cells of the thyroid gland
Clinical data of 120 cases of neonatal sepsis in our hospital were collected as the subjects of the study, and the application value of cefotaxime combined with gamma globulins in the treatment of neonatal sepsis was retrospectively analyzed
Summary
C-reactive protein (CRP) is the name of a protein that is synthesized in the liver in response to factors released from macrophages and fat cells, which in cases of inflammation and rheumatism in the blood increases. procalcitonin (PCT) is a precursor to the hormone calcitonin, which is produced in the C-cells of the thyroid gland. C-reactive protein (CRP) is the name of a protein that is synthesized in the liver in response to factors released from macrophages and fat cells, which in cases of inflammation and rheumatism in the blood increases. CRP and PCT are known as biomarkers used to neonatal sepsis diagnose [1,2,3,4,5]. Sepsis is a clinically common disease in neonates, and the incidence is higher in premature and low birth weight neonates. Due to the increasing number of drug-resistant strains and the non-specific and specific immune function defects in the body of the children, pathogenic bacteria rapidly spread in the body after infection. Conventional antibiotics cannot achieve good therapeutic effects and the case fatality rate of neonatal sepsis increases year by year [4,5]. Clinical data of 120 cases of neonatal sepsis in our hospital were collected as the subjects of the study, and the application value of cefotaxime combined with gamma globulins in the treatment of neonatal sepsis was retrospectively analyzed
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