Efficacy of Carnosine administration along with or without Coenzyme Q10 on sodium valproate induced testicular toxicity in vivo models

Abstract

Background and aimIn the present study, the effect of carnosine along with or without Coenzyme Q10 was tested on the sodium valporate induced testicular toxicity in male rats. Methods: The five different treatments were designed and its biological, relative weight of reproductive organs, serum lipid profiles, reproductive hormones levels and sperm motility factors were evaluated to provide a possible alternative to meet the problem of infertility in males. Results: the experimental rats showed a significant decrease in body weight gain and no difference was recorded feed intake and feed efficiency ratio in different treatments. The treatment of Carnosine along with CoQ10 does not produce any significant change in the relative weight of prostate in SVA induced rats. Further, the SVA induced male rats treated with the combination of Carnosine and CoQ10 showed significant decrease in total cholesterol, triglycerides and a significant increase in HDL-c, LDL-C, VLDL-C levels as compared to control. The same treatment resulted in the significant improvement in the reproductive hormones like testosterone, FSH and LH levels in the serum. Also, the biochemical parameters such as SOD, GST, GPX and catalase levels increased and decreased MDA serum antioxidant level when treated with both Carnosine and CoQ10. Conclusions: The combination of Carnosine and CoQ10 showed a succeeding increase in sperm motility even after 6 h of sperm storage. Thus, the obtained results from current study proved that the carnosine along with CoQ10 may be best alternative solution to treat male infertility.