Abstract
Purpose: To assess the effectiveness of calcium sodium phosphosilicate in reducing dentin hypersensitivity compared to other dentin tubule occluding molecules.
 Methods: A structured research question was formulated, and an electronic search of available literature was carried out via PubMed, Google Scholar, and Scopus. A hand search as well as a gray literature search were also carried out. The search produced a total of 67 articles. Of these, only eight articles were eligible to be included in our review. Risk of bias and study quality were checked using Cochrane tool. The review was registered in The International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD42018096200.
 Results: The results show a reduction in dentin hypersensitivity with calcium sodium phosphosilicate compared to many other molecules. However, nanohydroxyapatite showed a better desensitizing effect compared to Novamin.
 Conclusion: According to the available evidence, 5 % calcium sodium phosphosilicate containing toothpaste is more effective reducing dentin hypersensitivity compared to many other dentinal tubule occluding molecules.
Highlights
Dentin hypersensitivity (DH) is usually defined as acute sharp lingering pain associated with exposure of dentinal tubules to thermal, evaporative, tactile, or chemical stimuli which can’t be attributed to any other dental pathology or anomaly [1]
Females are more affected by DH than males [3].Dentin hypersensitivity is one of the main problems for which patients seek dental treatment [2]
We systematically reviewed randomized clinical trials (RCTs) to investigate our research question
Summary
Dentin hypersensitivity (DH) is usually defined as acute sharp lingering pain associated with exposure of dentinal tubules to thermal, evaporative, tactile, or chemical stimuli which can’t be attributed to any other dental pathology or anomaly [1]. Gingival recession is the most frequent etiology of DH, followed by attrition and erosions. Dentinal tubule exposure due to dental caries and attrition usually occurs in children and young adults. Gingival recession due to periodontal disease and following periodontal treatment is more frequent in older patients. Females are more affected by DH than males [3].Dentin hypersensitivity is one of the main problems for which patients seek dental treatment [2]
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