Efficacy of Bovine-derived Xenograft and Minimally Invasive Surgical Technique in the Treatment of Human Periodontal Intrabony Defects - A Systematic Review and Meta-analysis

Abstract

ABSTRACT Aim: The aim of this study was to evaluate the efficacy of minimally invasive surgical technique (MIST) with the use of bovine-derived xenograft (BDX) in the treatment of intrabony defects. Materials and Methods: An electronic search using PUBMED, Google Scholar, Google, Clinical Trials Registry, and Web of Science and manual search using Dr. D. Y. Patil Dental College library resources was conducted. Randomized controlled trials and case cohorts were included in this study. Case reports, reviews, and in vitro studies were excluded from the study. Meta-analysis was conducted to assess differences in clinical parameters (pocket probing depth, clinical attachment level, gingival recession) between MIST and MIST with BDX. Results: Both MIST alone and with xenograft showed statistically significant improvements in all the clinical and radiographic parameters. However, MIST alone showed marginally better improvement as compared to MIST with xenograft. Conclusions: MIST with or without BDX improves clinical, radiographic, and patient-related outcomes for treating intrabony defects. The improvement in the outcomes of MIST alone is found to be comparatively similar when used along with BDX suggesting that the benefits of MIST are not improved by xenograft.