Abstract
Biochemical catabolic biomarkers receive increasing attention in early stage of osteoarthritis (OA), due to superior sensitivity and objectivity in comparison to conventional endpoints. While previous studies with biochemical biomarkers in OA have focused primarily on structural changes, this study focused on early OA stage associated knee pain. Early determination would allow progressing personalized treatment choices and leading to better management of patients with OA.
Highlights
Osteoarthritis (OA) is a low-grade inflammatory disease of synovial joints and by far the most common form of arthritis [2]
There was a significant positive correlation observed between difference of CTX-II and visual analogue scale (VAS) score (r=0.40, p0.05)) between differences of Serum Cartilage oligomeric matrix protein (COMP) and VAS score (Table 4 & Figure 4)
Our study showed a significantly difference improvements in Urinary CTX-II and VAS score in early symptomatic knee osteoarthritis (ESKOA) patients after receiving Avocado/ soybean Unsaponifiable (ASU) treatment for six months in a single am clinical study
Summary
Osteoarthritis (OA) is a low-grade inflammatory disease of synovial joints and by far the most common form of arthritis [2]. The major risk factors for OA development include age, obesity and metabolic disease [6,7]. The pathogenesis and progression of OA is influenced by several factors including bone shape and joint dysplasia [10], obesity [11], synovitis [12], complement proteins [13], inflammatory mediators [14], inflammaging [15,16], innate immunity [17], Ortho & Rheum Open Access J 16(1): OROAJ.MS.ID.555927 (2020). While previous studies with biochemical biomarkers in OA have focused primarily on structural changes, this study focused on early OA stage associated knee pain.
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