Efficacy of application of the luteotropic drug for the prevention of intrauterine growth restriction in dairy cows

Abstract

Purpose: studying the effectiveness of the use of luteotropic action for preventing embryonic development disorders.Materials and methods. The research object is lactating animals in 60-75 days after a selection that manifests sex cyclicity and separated into 4 groups. The first group (n = 11) – in the insemination of parenterally injected the preparation of tautin at a dose of 5 ml. The second group (n = 11) – tautin was administered at a dose of 10 ml on the same time as cows of the first group. The third group (n = 12) – tautin injected 10 ml twice: during seeding and on the 14th day after seeding. The fourth group (n = 12) – was injected with saline per day of seeding and on the 14th day at a dose of 10 ml (negative control). Conducted a transrectal and ultrasound study at the end of the 1st and 2nd month of gestation, in which the size of the yellow body of pregnancy, embryo and the fetus was taken into account. Upon completion of pregnancy, all animals are taken into account: the nature of the flow of labor (physiological flow, objectiveness, fulbirth, detention, postpartum), postpartum period (physiological flow, submissiveness of the uterus, endometritis), the state of newborn calves (gender of the fetus, the time of manifestation of confident poses of standing, sucking reflex, body mass).Results. It has been established that the twofold administration of the tautin during seeding and on the 14th day after a dose of 10,0 ml is accompanied by an increase in fertilization by 19,7-28,8%, a decrease in the delay syndrome of the fetus development of 1,4-4,0 times, Absence of embryonic mortality. The use of the drug Tautin twice in a dose of 10,0 ml is accompanied by an increase in the size of the yellow body of pregnancy in 1,43-2,15 times, in comparison with other modes of its use, cockerel-dump-sized – by 12,9-37,6% and diameter Cases – by 10,1-46,6%. The use of a luteotropic drug is accompanied by a decrease in the incidence of cows to the detention of the last 1,8 times, the submissive of the uterus – 1,8 times, endometritis – by 2,7 times, the time of manifestation of confident posture of the standing of newborns of newborn calves – by 15,6 minutes, a sucking reflex – on 16,5 min and diarrheal syndrome – 2,7 times.Conclusion. The scientific novelty of research lies in the fact that new knowledge is obtained on the effectiveness of the use of the drug of luteotropic action, created using the technology of recombinant proteins, for the prevention of violations of embryonic development in cows.