Abstract
Efficacy of antioxidant supplementation on conventional and advanced sperm function tests in patients with idiopathic male infertility
Highlights
Treatment of patients with idiopathic male infertility with FH-PRO antioxidant regimen for 3 months resulted in significant improvement in conventional semen parameters and advanced tests of sperm function
In 72 out of 246 (29.3%) men, sperm recovery was successful with micro-TESE operation
In our idiopathic non-obstructive azoospermia (INOA) cohort, we found that 33% of the men have parental consanguineous marriage (PCM)
Summary
Testicular hyperthermia has been considered the primary pathophysiology leading to spermatogenic dysfunction in patients with varicocele. This study aims to compare scrotal and inguinal temperature measurements between varicocele patients and normal controls linking such measurement with semen parameter results. MATERIALS AND METHODS: Patients presenting with left clinical varicocele to our male infertility unit over a period of 1 year were included. Conventional semen analysis (WHO 2010) and oxidation reduction potential (ORP) measurement (MiOXSYS, Aytu Bioscience, Englewood, USA) were performed on all study participants. Varicocele patients were classified into normal semen (group II; n1⁄457); and abnormal semen (group III; n1⁄422) (R1 abnormal parameter). Bilateral scrotal and inguinal infrared digital thermographic imaging (FLIR E6, FLIR systems, Wilsonville, USA) was performed on patients and controls. Temperature measurements were compared between all study groups using ANOVA. Inguinal & right scrotal temperatures were significantly higher in group III compared with controls. Left Scrotal temp (c) 33.1 Æ 0.8* Right Scrotal temp (c) 32.9 Æ 0.9* Left Inguinal temp (c) 34.3 Æ 1.0* Right inguinal temp (c) 33.9 Æ 1.1
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