Efficacy of Anti-Reflux Medications on Improvement of Symptoms of Reflux Laryngitis

Abstract

Abstract Objectives/Hypothesis reflux laryngitis is an inflammatory condition of the upper airway tract tissues due to the effect of gastric or duodenal content reflux, which provokes morphological changes in the upper aero digestive tract. Reflux laryngitis related symptoms affect up to 50% of patients in the Division of Laryngology. The purpose of this systematic review to shed light on the current therapeutic strategies used for the management of reflux laryngitis in order to determine the efficacy on improvement of symptoms. Methods the included studies published between 2003 and 2018. Regarding the type of included studies. All patients who suffer from reflux laryngitis in otorhinolaryngology clinics in included studies and treated by proton pump inhibitors or H2 blockers or prokinetics were added. Reviewed papers should include degree of improvement of any of the following symptoms: hoarseness, cough, Globus sensation, sore throat, dysphonic attacks, throat clearing non-productive cough, dysphagia, excessive throat mucus, etc. When using antireflux medications. Results The demographic characteristics and clinical data in all 15 studies are shown in the following tables: #Studies were arranged according to publication year. This table showed that; the included studies published between 2003 and 2018. The search identified 49 relevant papers, of which 15 studies met the inclusion criteria, accounting for 990 patients. The main therapeutic scheme consisted of once or twice daily PPIs for a duration ranged from 4 to 24 wk. The most used PPIs were omeprazole, esomeprazole, rabeprazole, lansoprazole and pantoprazole with a success rate ranging from 18% to 87%. Other composite treatments have been prescribed including PPIs, prokinetics, and H2 Receptor antagonists. Conclusions LPRD is more common in the age group of 31-40 years and proton pump inhibitors and prokinetics are highly effective in controlling laryngeal reflux symptom index and laryngeal reflux finding score.