Abstract
Background Animal models are well established for studying the effects of alkaloids in preventing myocardial ischemia-reperfusion injury. However, few studies have investigated the therapeutic effects of alkaloids in humans. This meta-analysis and systematic review assessed the efficacy of alkaloids in attenuating infarct size in rats with myocardial ischemia-reperfusion injury. Methods An integrated literature search including the PubMed, Embase, and Cochrane Library databases was performed to identify studies that evaluated the therapeutic effects of alkaloids on myocardial ischemia-reperfusion injury in rats. The main outcome was infarct size, and SYRCLE's risk of bias tool was used to assess the quality of the studies. Results 22 studies were brought into the meta-analysis. Compared with the effects of vehicle, alkaloids significantly reduced infarct size (standardized mean difference (SMD) = −0.45; 95% confidence interval (CI) = −0.64 to − 0.26). In subgroup analyses, isoquinoline alkaloids (SMD = −0.43; 95%CI = −0.70 to − 0.16) significantly reduced infarct size versus the control. Conclusion Isoquinoline alkaloids can potentially alleviate myocardial ischemia-reperfusion injury. This meta-analysis and systematic review supply a reference for research programs aiming to develop alkaloid-based clinical drugs. This trial is registered with CRD42019135489.
Highlights
Myocardial infarction (MI) constitutes the main cause of morbidity and mortality in patients with coronary heart disease globally [1, 2]
Some studies illustrated that natural compounds, such as alkaloids, flavonoids, and terpenoids, attenuate myocardial I/R injury [6,7,8]
Based on previous animal studies, alkaloids have the potential to attenuate myocardial I/R injury. Parameters such as the age and gender of animals, sample size, route type, and duration of ischemia and reperfusion varied among the studies
Summary
Myocardial infarction (MI) constitutes the main cause of morbidity and mortality in patients with coronary heart disease globally [1, 2]. Animal models are well established for studying the effects of alkaloids in preventing myocardial ischemia-reperfusion injury. Few studies have investigated the therapeutic effects of alkaloids in humans This meta-analysis and systematic review assessed the efficacy of alkaloids in attenuating infarct size in rats with myocardial ischemia-reperfusion injury. An integrated literature search including the PubMed, Embase, and Cochrane Library databases was performed to identify studies that evaluated the therapeutic effects of alkaloids on myocardial ischemia-reperfusion injury in rats. Isoquinoline alkaloids can potentially alleviate myocardial ischemia-reperfusion injury. This meta-analysis and systematic review supply a reference for research programs aiming to develop alkaloid-based clinical drugs.
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