Abstract
BackgroundSoil transmitted helminths (STH) are intestinal nematodes and constitute one of the most neglected tropical diseases to exist. Objective: This study determined the efficacy of albendazole-pyrantel pamoate compared to albendazole in 8–12 years old children with Trichuris trichiura infection.MethodsA randomised controlled trial was conducted between October 2017 and February 2018 on participants whose stool examinations confirmed the presence of Trichuris trichiura infection. The subjects were randomised into two groups. The statistical analysis used Chi-square test.ResultsThere were 392 of 600 children at five public elementary schools in Bangli and Bali and were infected with Trichuris trichiura. The cure rate of Trichuris trichiura infection seven days following treatment was lower with the combination of albendazole and pyrantel pamoate compared to that of albendazole. The egg reduction rate of Trichuris trichiura infection was lower with the combination of albendazole and pyrantel pamoate compared to albendazole.ConclusionThe study indicated that a combination of albendazole and pyrantel pamoate does not improve cure rate or egg reduction rate in 8–12 years old children with Trichuris trichiura infection.
Highlights
Soil transmitted helminths (STH) infections are considered to be intestinal nematode and constitute one of the most important but neglected tropical diseases to exist
The study indicated that a combination of albendazole and pyrantel pamoate does not improve cure rate or egg reduction rate in 8–12 years old children with Trichuris trichiura infection
This study indicated that the efficacy of albendazole and pyrantel pamoate was higher compared to just using albendazole in children with Trichuris trichiura infection
Summary
Soil transmitted helminths (STH) infections are considered to be intestinal nematode and constitute one of the most important but neglected tropical diseases to exist. Health Organization (WHO) reported that more than two billion people have been infected with Ascaris lumbricoides, 750 million with Trichuris trichiura and another 900 million with hookworm [2, 3]. –. In the past ten years, it has been reported that Bali is an area with a high incidence rate of STH infection [4, 5]. The most common types of STH in children are Ascaris lumbricoides and Trichuris trichiura. Soil transmitted helminths (STH) are intestinal nematodes and constitute one of the most neglected tropical diseases to exist
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