Abstract
Osteoradionecrosis (ORN) is a common consequence resulting from radiation in patients with cancer. Presently, hyperbaric oxygen therapy (HBOT) is proposed to have a role in improving wound healing in ORN patients. There is no strong scientific evidence to confirm the benefits of HBOT for treatment of ORN as an adjunctive treatment. This study aimed to determine the benefits of adjunctive treatment of HBOT in ORN. A retrospective study was conducted at the Srinagarind Hospital, the Faculty of Medicine, Khon Kaen University, Thailand, between 2011 and 2017. The patients diagnosed with ORN, who received adjunctive HBOT before the operation, were enrolled. Complete healing of wounds was the primary outcome. There were 84 ORN patients with a mean age of 58.78 years; 54.76% were male and 45.24% were female. HBOT had a role significant in improving wound healing of ORN patients with stages 1 and 2. Poisson regression analysis showed that stage 3 of ORN negatively correlated with the number of HBOT dives (p = 0.001, incidence rates ratio = 0.85). In conclusion, HBOT improved wound healing of ORN patients with stages 1 and 2. In addition, stage 2 of ORN patients significantly required the highest number of HBOT dives compared to other types of ORN to promote wound healing, whereas stage 3 patients, who underwent bone debridement combined with HBOT, initiated to success of treatment process and required a smaller number of dives.
Highlights
Osteoradionecrosis (ORN) is a common consequence resulting from radiation in patients with cancer.[1,2] The most commonly affected bone is the mandible.[3,4]Patients with this malignancy generally receive conventional therapy, including surgery, chemotherapy, and radiation
Materials and Methods The retrospective study design was to determine the influence of hyperbaric oxygen therapy (HBOT) in ORN patients
The inclusion criteria for this study were all stages of ORN patients, who received HBOT as adjunctive prophylactic treatment before and after the procedure
Summary
Osteoradionecrosis (ORN) is a common consequence resulting from radiation in patients with cancer.[1,2] The most commonly affected bone is the mandible.[3,4]Patients with this malignancy generally receive conventional therapy, including surgery, chemotherapy, and radiation. Osteoradionecrosis (ORN) is a common consequence resulting from radiation in patients with cancer.[1,2] The most commonly affected bone is the mandible.[3,4]. Ionizing radiation almost certainly has an unfavorable effect on soft and hard tissues.[5,6,7,8] affected soft tissues have been damaged and this has caused progressive endarteritis, hyalinization, and fibrosis. These lead to ischemia of affected tissues. These adverse events have occurred in bone, resulting in destruction of local vascular systems and cellular components.[9,10]
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