Abstract
BackgroundThe efficacy of a novel inactivated intradermal Lawsonia intracellularis vaccine, Porcilis® Lawsonia ID, was evaluated in two experimental vaccination-challenge studies and under field conditions on a farm with a history of recurrent acute ileitis. In addition, the efficacy of the vaccine was compared to that of a commercially available live attenuated vaccine. The novel inactivated vaccine consists of a freeze-dried antigen fraction that is dissolved just prior to use in either the adjuvant or in Porcilis® PCV ID; an existing intradermal vaccine against porcine Circovirus type 2. In the two experimental vaccination-challenge studies, groups of 25 piglets were vaccinated once at 3 weeks of age or left unvaccinated as challenge control. Vaccines tested were Porcilis® Lawsonia ID as standalone (study 1) or in associated mixed use with Porcilis® PCV ID (study 2) and an orally administered commercially available live vaccine (study 1). The pigs were challenged with virulent L. intracellularis at 4 weeks (study 1) or 21 weeks (study 2) after vaccination. Post-challenge, the pigs were evaluated for clinical signs, average daily weight gain, shedding and macroscopic as well as microscopic immuno-histological ileum lesion scores. In the field study, the mortality and key performance parameters were evaluated over a period of 8 months.ResultsThe results of the two experimental vaccination-challenge studies showed that Porcilis® Lawsonia ID as single vaccine or in associated mixed use with Porcilis® PCV ID, induced statistically significant protection against experimental L. intracellularis infection, 4 weeks or 21 weeks after vaccination. This was demonstrated by lower clinical scores, improved weight gain, reduction of L. intracellularis shedding and reduction of macroscopic as well as microscopic ileum lesion scores when compared to the controls. The protection induced was superior to that of the commercially available live vaccine. In the field study Porcilis® Lawsonia ID was highly efficacious in reducing L. intracellularis associated mortality and improving key production parameters.ConclusionThe results support that this new intradermal vaccine is efficacious against L. intracellularis and may be used in associated mixed use with Porcilis® PCV ID.
Highlights
The efficacy of a novel inactivated intradermal Lawsonia intracellularis vaccine, Porcilis® Lawsonia ID, was evaluated in two experimental vaccination-challenge studies and under field conditions on a farm with a history of recurrent acute ileitis
Lawsonia intracellularis is the cause of Porcine Proliferative Enteropathy (PPE) known as Porcine Intestinal Adenomatosis (PIA) or ileitis [1,2,3,4]
For each of the two studies 75 or 50 piglets, from a farm known to be negative for Mycoplasma hyopneumoniae (M Hyo) and Porcine Reproductive & Respiratory Syndrome Virus (PRRSV) and no history of PPE, were randomly allotted to three or two groups of 25 piglets each, respectively
Summary
The efficacy of a novel inactivated intradermal Lawsonia intracellularis vaccine, Porcilis® Lawsonia ID, was evaluated in two experimental vaccination-challenge studies and under field conditions on a farm with a history of recurrent acute ileitis. The infection can lead to an acute haemorrhagic form of the disease, but the bacterium infects pigs sub-clinically without clear clinical signs, but still resulting in reduced growth performance [5]. Both inactivated and live attenuated vaccines are being used in the pig industry against the disease [6, 7](http://www.enteric.solutions/), no intradermal vaccines have been available until now. Combined with needle-free administration, ID vaccination is more animal friendly and prevent accidental transmission of pathogens caused by re-using needles as well as broken needles in the muscle and derived consumer products
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