Abstract
The combination of the directed transport of magnet-driven liposomal forms of drugs to a target organ and the local action of the applied magnetic field is a promising direction for the development of new corticosteroid preparations possessing pronounced antiinflammatory activity. The antiinflammatory properties of magnet-driven liposomes containing prednisolone, liposomal prednisolone, magnet-driven liposomes, and 0.5% prednisolone ointment were evaluated in a comparative test on animals with a model of allergic dermatitis. The magnet-driven liposomes with prednisolone were prepared by means of the evaporation-phase inversion method, using a mixture of phospholipids and cholesterol obtained from cattle brain. Finely dispersed magnetite was used as a magnetic carrier. The experiments showed that the magnet-driven liposomes with prednisolone produce a more pronounced antiinflammatory action than the pure ointment.
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