Efficacy of a Gluten-Free Diet in the Gilles de la Tourette Syndrome: A Pilot Study.

Luis Rodrigo,Enrique Fernández-Bustillo,Nuria Álvarez,Marcos Huerta,Carlos Hernández-Lahoz,Javier Salas-Puig

doi:10.3390/nu10050573

Luis Rodrigo, Enrique Fernández-Bustillo + Show 4 more

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https://doi.org/10.3390/nu10050573

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Abstract

The Gilles de la Tourette syndrome (GTS) and Non-Coeliac Gluten Sensitivity (NCGS) may be associated. We analyse the efficacy of a gluten-free diet (GFD) in 29 patients with GTS (23 children; six adults) in a prospective pilot study. All of them followed a GFD for one year. The Yale Global Tics Severity Scale (YGTSS), the Yale-Brown Obsessive-Compulsive Scale—Self Report (Y-BOCS) or the Children’s Yale-Brown Obsessive-Compulsive Scale—Self Report (CY-BOCS), and the Cavanna’s Quality of Life Questionnaire applied to GTS (GTS-QOL) were compared before and after the GFD; 74% of children and 50% of adults were males, not significant (NS). At the beginning of the study, 69% of children and 100% of adults had associated obsessive-compulsive disorder (OCD) (NS). At baseline, the YGTSS scores were 55.0 ± 17.5 (children) and 55.8 ± 19.8 (adults) (NS), the Y-BOCS/CY-BOCS scores were 15.3, (standard deviation (SD) = 12.3) (children) and 26.8 (9.2) (adults) (p = 0.043), and the GTS-QOL scores were 42.8 ± 18.5 (children) and 64 ± 7.9 (adults) (p = 0.000). NCGS was frequent in both groups, with headaches reported by 47.0% of children and 83.6% of adults (p = 0.001). After one year on a GFD there was a marked reduction in measures of tics (YGTSS) (p = 0.001), and the intensity and frequency of OCD (Y-BOCS/CY-BOCS) (p = 0.001), along with improved generic quality of life (p = 0.001) in children and adults. In conclusion, a GFD maintained for one year in GTS patients led to a marked reduction in tics and OCD both in children and adults.

Highlights

The Gilles de la Tourette syndrome (GTS) is a chronic neuropsychiatric process of unknown cause.It is characterised by the presence of multiple motor tics and at least one vocal or phonic tic
After one year on a gluten-free diet (GFD) there was a marked reduction in measures of tics (YGTSS) (p = 0.001), and the intensity and frequency of obsessive-compulsive disorder (OCD) (Y-BOCS/Children’s Yale-Brown Obsessive-Compulsive Scale—Self Report (CY-BOCS)) (p = 0.001), along with improved generic quality of life (p = 0.001) in children and adults
We found a significant improvement in the neurological signs of GTS after one year on the GFD, with a notable reduction in motor and vocal/phonic tics and OCD symptoms, both in children and adults

Summary

Introduction

The Gilles de la Tourette syndrome (GTS) is a chronic neuropsychiatric process of unknown cause It is characterised by the presence of multiple motor tics and at least one vocal or phonic tic. Both types of tic are usually intermittent, not necessarily concurrently. They are of variable frequency, with periods of intensification and remission, persisting for more than a year, from the appearance of the first tic [1]. This disorder begins in childhood or adolescence before the age of 18 years [1]. Tic severity worsens throughout childhood and for most patients, the worst ever period of tics occurs between 8

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