Abstract
Abstract Objective To investigate the effects of 5-hydroxytryptamine 3 receptor antagonists (ondansetron [OND]) versus dopamine receptor antagonists (droperidol [DRO]) in the prevention of postoperative nausea, vomiting (PONV) and headache by pooling data from open published studies. Methods Performed systematic electronic searches of PubMed, Embase, Google scholar and CNKI, to identify open-published prospective randomized controlled trials (RCTs) relevant to the comparison of OND versus DRO for preventing PONV and headache to be included in the present study. The pooled PONV, headache, dizziness and drowsiness were calculated based on the original data of each included study. The pooled data was presented with risk ratio (RR) and 95% confidence interval (95%CI). Results Thirteen prospective randomized clinical trials were included in this meta-analysis. The pooled PONV, post-operative nausea (PON) and positive operative vomiting (POV) were 0.67 (95%CI:0.48-0.93, p<0.05), 0.88 (95%CI:0.67-1.14, p>0.05) and 0.56 (95%CI:0.39-0.82,p<0.05) respectively for OND vs. DRO. And the overall pooled positive operative nausea and vomiting was 0.71(95%CI:0.60-0.86) by fixed effects model for OND vs. DRO. The pooled risk of postoperative headache, dizziness and drowsiness were 4.33 (95%CI:0.76-24.69, p>0.05), 0.63 (95%CI:0.21-1.87, p>0.05) and 0.48(0.28-0.81,p<0.05) respectively by fixed effect model for OND vs. DRO. Conclusion The post-operative nausea, vomiting and dizziness risks were significant decreased for patients receiving OND compared to patients receiving DRO.
Highlights
Post-operative nausea and vomiting (PONV) is common complication in patients who receive general anesthesia [1,2,3]
We performed a meta-analysis by pooling the data of relevant open-published studies, with the goal of strengthening the statistical power of analyses to quantify the clinical efficacy of ondansetron versus droperidol in preventing PONV
Open-published prospective randomized controlled trials (RCTs) relevant to efficacy of 5-hydroxytryptamine 3 receptor antagonists versus dopamine receptor antagonists for preventing postoperative nausea, vomiting and headache were screened in the electronic databases of PubMed, Embase, Google scholar and CNKI by the text word of ondansetron, droperidol, post-operative, nausea, vomiting
Summary
Post-operative nausea and vomiting (PONV) is common complication in patients who receive general anesthesia [1,2,3]. Clinical studies have indicated that this complication develops in one of ten patients who undergo general anesthesia [4, 5]. A postoperative antiemetic is generally given to patients who received general anesthesia. Several studies have evaluated the clinical efficacy of both ondansetron [8,9,10] and droperidol [11, 12] in the prevention of PONV. We performed a meta-analysis by pooling the data of relevant open-published studies, with the goal of strengthening the statistical power of analyses to quantify the clinical efficacy of ondansetron versus droperidol in preventing PONV
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
