Efficacy observation of hydroxycamptothecin combined irrigation of interleukin-2 against postoperative recurrence of non- muscle invasive bladder cancer

Abstract

Objectives To evaluate the efficacy and safety of hydroxycamptothecin(HCPT) combined irrigation of int erleukin-2 against postoperative recurrence of non- muscle invasive bladder cancer (NMIBC). Methods 152 patients with NMIBC were radomly divided into control group (HCPT) and combination group (HCPT+ IL-2). After trans-urethral resection bladder tumor(TURBT), all patients received perfusion therapy, once a week for eight weeks to once a month, a total of one year. The recurrence rate and adverse reaction were observed in two groups. Results Follow up 2 years, recurrence rate in control group and combination group was 23.6% (18/76), 10.5%(8/76)respectively. There was statistically significant difference (χ2=4.640, P 0.05). Conclusions HCPT combined irrigation interleukin-2 against postoperative recurrence of NMIBC is better than hydroxycamptothecin only, which has the advantages of low rate of adverse reactions, good tolerance as a first-line therapy of drug perfusion. Key words: Urinary Bladder Neoplasms; Cystectomy; Camptothecin; Neoplasm Recurrence, Local