Abstract
目的 观察雷替曲塞联合顺铂同步放化疗治疗中晚期食管癌的近期疗效及患者不良反应。 方法 回顾性分析58例采取同步放化疗的中晚期食管癌患者临床资料,分为治疗组28例和对照组30例,治疗组给予雷替曲塞联合顺铂方案同步放疗59.4~60.0 Gy;对照组给予顺铂联合5-氟尿嘧啶方案同步放疗59.4~60.0 Gy。治疗后3个月评价患者疗效及不良反应。计量资料采用t检验,计数资料采用χ2检验。 结果 治疗组近期缓解率为92.9%(26/28),高于对照组近期缓解率的83.3%(25/30),但差异无统计学意义(P>0.05);两组不良反应主要表现为1~2级的骨髓抑制、放射性肺炎、放射性食管炎以及恶心、呕吐,其发生率分别为39.3%、17.9%、57.1%、42.9%(治疗组),23.3%、20.0%、50.0%、43.3%(对照组),差异均无统计学意义(均P>0.05)。 结论 雷替曲塞联合顺铂同步放疗治疗中晚期食管癌近期疗效不差于FP方案同步联合放疗,具有给药方便、依从性好的优势,安全可行。
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