Abstract
There is a significant research gap in meta-analysis on the efficacy and safety of coronavirus disease 2019 (COVID-19) vaccines. This study analyzed the efficacy of COVID-19 vaccines. Published phase I, phase II, and phase III trials analyzing safety and immunogenicity and phase III randomized clinical trials evaluating the efficacy of COVID-19 vaccines were included. We searched MEDLINE, Scopus, and The Lancet for published articles evaluating the relative reduction in COVID-19 risk after vaccination. Selected literatures were published between December 15, 2019 and May 15, 2021 on the safety, efficacy, and immunogenicity of COVID-19 vaccines. This meta-analysis included studies that confirmed cases of COVID-19 using reverse transcriptase polymerase chain reaction. This study detected 8,926 eligible research articles published on COVID-19 vaccines. Of these, 25 studies fulfilled the inclusion criteria. Among the selected articles, 19 randomized clinical trials, 2 non-randomized clinical trials, and 3 observational studies were analyzed. Seven (28%) studies were included in the meta-analysis. The efficacy of the adenovirus vector vaccine was 73% (95% CI = 69–77) and that of the messenger RNA (mRNA) vaccine was 85% (95% CI = 82–88) in participants aged ≥18 years. There are no reports of clinical trials in participants aged under 16 years. The production of neutralizing antibodies against receptor-binding domains (RBDs) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in >90% of the vaccinated samples was reported within 0–30 days of the first or the second dose of the vaccine. Pain at the injection site was the most common local symptom in people receiving mRNA vaccines (29%–85% of participants). Fever (0.2%–95%) was the most prevalent in people receiving adenovirus vector vaccines, and fatigue (8.4%–55%) was the most common side effect in people receiving the mRNA vaccines. Studies suggest that mRNA vaccines and adenovirus vector vaccines can provide moderate to high protection against COVID-19 infection in people over 18 years. Evidence of the long-term protection of the vaccines in people aged under 16 years against the multiple variants of COVID-19 are limited. This study will provide an integrated evaluation on the efficacy, safety, and immunogenicity of the COVID-19 vaccines.
Highlights
A novel species of coronavirus, namely, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has set out the coronavirus disease 2019 (COVID-19) pandemic from December 2020 [1]
The efficacy of a COVID-19 vaccine was defined as the relative reduction in SARS-CoV-2 infection risk following vaccination, as determined by previously published randomized placebocontrolled clinical trials [26, 30, 32, 37]
This study found 8,926 research articles on COVID-19 and SARS-CoV-2 vaccines by using the previously mentioned search terms (Figure 1)
Summary
A novel species of coronavirus, namely, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has set out the coronavirus disease 2019 (COVID-19) pandemic from December 2020 [1]. About 150 million cases and 3.2 million fatalities associated with COVID-19 have been confirmed globally [2, 3]. Children and younger adults are becoming infected with COVID-19 and are having serious health problems [4]. The number of illnesses and fatalities are continuously increasing [2, 3]. If adequate preventive actions are not performed quickly, COVID-19 will have serious and long-term medical, social, economic, and mental effects [9, 10]
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