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Abstract
Background/Objective: Dryness is considered to be an early developmental mechanism of wrinkles, and fine line formation is marked in atopic dermatitis (AD) accompanied by dry skin. To evaluate the efficacy of a skincare product with a moisturizing effect increased by lamellar formulation of pseudo-ceramide for fine lines and wrinkles, a use test was performed applying the product to non-lesional dry skin in patients with atopic dermatitis. Method: The test product was an essence containing pseudo-ceramide formulated in a lamellar structure. The study design was a nine-week single-center non-comparative study, and the evaluation items were the grade of wrinkles at the corners of the eyes judged by a dermatologist, replica analysis, and instrumental measurement (skin surface moisture and transepidermal water loss). Results: Nine-week continuous use of the test product significantly improved the score of wrinkles at the corners of the eyes judged by a dermatologist and wrinkle area ratio on replica analysis of the corners of the eyes and cheeks, compared with those at study initiation. With this improvement, the losses of skin surface moisture and transepidermal water were also significantly improved. Conclusion: It was clarified that the tested pseudo-ceramide-formulated skincare product not only improved the barrier function for atopic dermatitis, but also exhibited an effect on fine lines and wrinkles of dry skin.
Highlights
Reduced barrier function and dryness of skin are observed in atopic dermatitis (AD), and a lack of intercellular lipids in the stratum corneum, ceramide, is considered to be a cause of this, as it reduces skin surface moisture and increases transepidermal water loss in regions with eruptions and non-lesional regions [1] [2]
Since skin elasticity reduction and wrinkle formation are likely to occur in dry skin, fine lines are readily formed due to reduced skin elasticity in AD, in addition to dryness-induced rough skin surface and scales, and the skin appearance negatively influences the quality of life (QOL) of patients [3] [4]
Of Japanese female patients diagnosed by a dermatologist with very mild to mild AD based on the atopic dermatitis severity index, 22 patients aged 26 - 51 years with a specified wrinkle score (1 - 3) of the corners of the eyes who gave informed consent participated in the study (Table 2)
Summary
Reduced barrier function and dryness of skin are observed in atopic dermatitis (AD), and a lack of intercellular lipids in the stratum corneum, ceramide, is considered to be a cause of this, as it reduces skin surface moisture and increases transepidermal water loss in regions with eruptions and non-lesional regions [1] [2]. Since skin elasticity reduction and wrinkle formation are likely to occur in dry skin, fine lines are readily formed due to reduced skin elasticity in AD, in addition to dryness-induced rough skin surface and scales, and the skin appearance negatively influences the quality of life (QOL) of patients [3] [4]. No evaluation of the antiwrinkle efficacy of ceramide-formulated preparations for non-lesional dry skin of AD patients has been reported. Improvement of dryness and barrier function by external use of ceramide and ceramide analogues in AD patients have been investigated, and a superior moisturizing effect and improvement of the barrier function have been clarified [5]. We performed a use test of a skincare product with a moisturizing effect increased by a lamellar formulation of pseudo-ceramide to confirm its efficacy for fine lines and wrinkles in AD patients
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