Efficacy comparison of interstitial cystitis/painful bladder syndrome patients treated with oral medication and Sodium hyaluronate intravesical instillation

Abstract

Objective To compare the outcomes between interstitial cystitis/bladder pain syndrome (IC/BPS) patients treated with three-drug combination (M blockers+ alpha blockers+ Amitriptyline) and Sodium hyaluronate intravesical instillation. Methods The patients who came to Second Affiliated Hospital of Nanjing Medical University during October 2014 to September 2015 were investigated if they had IC/BPS. According to the treatment plan, 27 patients (group A) received three-drug combination (M blocker+ alpha blockers+ Amitriptyline) therapy. Thirty-eight patients recelved instillation of sodium hyaluronate (40 mg/50 ml) therapy (group B). Intravesical instillations were performed weekly in the first 6 weeks, and monthly until sixth month. Interstitial cystitis symptom index, interstitial cystitis problem index, overactive bladder symptom score, visual analogue scale/score, the maximum urination and self-rating depression scale were assessed at baseline and the sixth month. Measurement data were expressed as (±s), t test was used for comparison between groups, and paired t-test was used for comparison of paired data. Results There were 65 patients. Age range was 25-73 years, course of disease (2-99 months), average age (51.4 ± 13.5), average duration (39.8 ± 31.0) months, of which 9 male (13.8%) and 56 female (86.2%) patients. The group A variation of ICSI、ICPI、OABSS、VAS、SDS and maximum urination were 3.7±2.4、1.3±1.5、1.2±1.3、2.1±1.5、3.1±4.5、74.6±52.4, The variation of group B ware 6.8±3.6、5.0±3.8、2.5±1.8、2.8±1.7、8.9±6.4、109.0±81.1.The improvement in ICSI, ICPI, OABSS, SDS of group B were higher than group A (P<0.05). Conclusion IC/BPS seriously affect the quality of life and the patients are prone to depression. The sodium hyaluronate intravesical instillation therapy could achieve more effect than the three-drug combination therapy. Key words: Cystitis; Interstitial; Drug therapy; Sodium hyaluronate