Efficacy comparison of atorvastatin versus rosuvastatin on blood lipid and microinflammatory state in maintenance hemodialysis patients

Jianwei Tian,Xiaoyan Hou,Liping Hu,Ting Chen,Kefei Wu,Chudan Cai,Xiaoyan Bai

doi:10.1080/0886022x.2016.1256309

Jianwei Tian, Xiaoyan Hou + Show 5 more

Open Access

https://doi.org/10.1080/0886022x.2016.1256309

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Abstract

Introduction: To investigate the effect of Atorvastatin (ATO) and Rosuvastatin (ROS) on blood lipid, high sensitivity CRP (hs-CRP), interleukin-6 (IL-6), albumin (ALB), prealbumin (PA), and transferring (TF) in maintenance hemodialysis (MHD) patients.Methods: Eighty MHD patients were enrolled and divided into two groups: ROS and ATO. Patients in Group ROS (n = 38) received ROS (10 mg/day), and those in group ATO (n = 42) received ATO (20 mg/day) for 12 weeks, respectively.Findings: Administration of ROS and ATO both significantly reduced the concentrations of TC, LDL-C, TG, hs-CRP, and IL-6, but increased high-density lipoproteincholesterol (HDL-C), ALB, PA, and TF levels. Furthermore, the level of LDL-C decreased more significantly with inhibited microinflammation and improved nutrition situation in ROS group compared with ATO group. ATO and ROS not only decreased blood lipid levels but also inhibited the microinflammatory state and improved nutrition situation in MHD patients.Discussion: The results have shown that ROS is better than ATO in the treatment of MHD patients.

Highlights

To investigate the effect of Atorvastatin (ATO) and Rosuvastatin (ROS) on blood lipid, high sensitivity CRP, interleukin-6 (IL-6), albumin (ALB), prealbumin (PA), and transferring (TF) in maintenance hemodialysis (MHD) patients
Malnutrition Inflammation Atherosclerosis (MIA) Syndrome is a common complication of hemodialysis, regarded as an important factor affecting the long-term survival rate of MHD patients
There are currently no effective drugs against microinflammation in dialysis patients. Macromolecular inflammatory cytokines such as CRP, IL-1, interleukin-6 (IL-6), and TNF-alpha, are difficult to be cleared by regular hemodialysis

Summary

Introduction

To investigate the effect of Atorvastatin (ATO) and Rosuvastatin (ROS) on blood lipid, high sensitivity CRP (hs-CRP), interleukin-6 (IL-6), albumin (ALB), prealbumin (PA), and transferring (TF) in maintenance hemodialysis (MHD) patients. The level of LDL-C decreased more significantly with inhibited microinflammation and improved nutrition situation in ROS group compared with ATO group. ATO and ROS decreased blood lipid levels and inhibited the microinflammatory state and improved nutrition situation in MHD patients. Malnutrition Inflammation Atherosclerosis (MIA) Syndrome is a common complication of hemodialysis, regarded as an important factor affecting the long-term survival rate of MHD patients. The cardiovascular events are the leading cause of death for ESRD patients and account for nearly half of the total mortality rate.[2] In recent years, the relationship between atherosclerosis and microinflammation as well as malnutrition has aroused great attention. Special attention was paid to the evaluation of these indexes while few reports were related with the treatment of MIA with medications

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