Efficacy comparison between two kinds of gastric bypass surgery for non-obese type 2 diabetes mellitus in rats

Abstract

Objective To compare the efficacies of Roux-en-Y gastric bypass(RYGBP) and billiopancreatic diversion(BPD) in treatment of rats with non-obese type 2 diabetes mellitus.Methods Totally 48 Goto-Kakizaki rats were randomized to undergo one of the following procedures: Roux-en-Y gastric bypass(n=16),biliopancreatic diversion(n=16),and sham operation(n=16).The fasting blood glucose and fasting insulin were determined before and 1,3,6,9,12,and 24 weeks after operation;the hematoglobin A_1c(HbA_1c) levels were determined before and 6,12,and 24 weeks after operation and the insulin resistance index(HOMA-IR) was calculated.The mortality and complications were observed in each group.Results The fasting blood glucose levels were significantly decreased during 1-24 weeks after operation in both Roux-en-Y group and biliopancreatic diversion group(P0.01 or P0.05);the HbA_1c levels were also decreased 12 and 24 weeks after operation(P0.01);and the above parameters were not significantly changed in the sham operation group.The fasting insulin levels were not significantly different between the 3 groups.In RYGBP group and the BPD group,the HOMA-IR indices decreased significantly 1-24 weeks after operation compared with those before operation(P0.05),and those in the BPD group were significantly lower than those in the RYGBP group at all time points(P0.05).The mortality was 6% in the RYGBP group and 50% in the BPD group.The complication rate and mortality in the BPD group were significantly higher than those in the RYGBP group(P0.05).Conclusion RYGBP and BPD have similar efficacies in treatment of rats with non-obese type 2 diabetes mellitus,and BPD can lead to higher incidences of complications and mortalities than RYGBP.