Abstract
Objective To systematically evaluate the efficacy and safety of XFZYD for coronary heart disease (CHD). Methods A comprehensive literature search of randomized controlled trials using XFZYD for CHD was conducted in 10 electronic databases from their establishment to December 20, 2020. The researchers screened the relevant trials in NoteExpress, extracted the data in duplicate independently, assessed the risk of bias in the trials using the Cochrane collaboration tool, and then used Rev Man 5.3 for data analysis. Results 30 trials with 3126 participants were included for meta-analysis. The results showed that the clinical effects of XFZYD and its combination with chemical drugs (CD) were 1.13 (RR; 1.13; 95% CI, 1.03 to 1.24) and 1.26 (RR; 1.26; 95% CI, 1.20 to 1.32) times those of CD, respectively. And, it could also improve electrocardiogram effect, which was 1.63 (RR; 1.63; 95% CI, 1.04 to 2.53) times that of CD. XFZYD could not only decrease duration of angina pectoris and improve vascular endothelial function but also obviously reduce the TCM syndrome score. When used in combination with CD, it could also lower AF, correct the dyslipidemia, and reduce the blood viscosity. Conclusion These results demonstrated that XFZYD had great advantages in treating CHD with no obvious adverse reactions. Therefore, it is believed that XFZYD is more suitable for CHD patients with clinical indicators of dyslipidemia, high blood viscosity, or vascular endothelial dysfunction. This study is the first systematic review and meta-analysis with some unique ways, including its comprehensiveness, large-scale search, the novelty of findings, and transparent approach.
Highlights
Coronary heart disease (CHD) is a heart disease caused by atherosclerotic lesions in the coronary arteries, which causes stenosis or obstruction of the vascular lumen, resulting in myocardial ischemia, hypoxia, or necrosis [1], and it is the main cause of death worldwide
Some drugs can delay the development of CHD to a certain extent, long-term medication will cause adverse reactions; for example, depression is a side effect of medication, which may aggravate the development of CHD [2]
Based on the above retrieval strategy, a total of 1880 potentially relevant trials were retrieved from 10 electronic databases, and 657 trials were retrieved after 1223 duplicates were deleted
Summary
Coronary heart disease (CHD) is a heart disease caused by atherosclerotic lesions in the coronary arteries, which causes stenosis or obstruction of the vascular lumen, resulting in myocardial ischemia, hypoxia, or necrosis [1], and it is the main cause of death worldwide. Due to its high morbidity and mortality, CHD has gradually become an important public health problem worldwide, and it has attracted extensive attention at home and abroad. Standardized treatments include drug and revascularization therapy. Some drugs can delay the development of CHD to a certain extent, long-term medication will cause adverse reactions; for example, depression is a side effect of medication, which may aggravate the development of CHD [2]. Traditional Chinese medicine (TCM) has long-term practice in the treatment of CHD, which belongs to the category of “chest pain” and “heartache” in TCM. Xue-FuZhu-Yu decoction (XFZYD) has the effects of promoting blood circulation for removing blood stasis and regulating qi-flowing
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