Efficacy and Safety of Tranexamic Acid Combined with Hydroquinone Cream in the Treatment of Chloasma

Abstract

To study the efficacy and safety of tranexamic acid and hydroquinone cream with water light needle in the treatment of chloasma, and to provide clinical reference for the treatment of Chloasma is the main objective. A total of 230 patients with chloasma admitted to Fuyang Maternal and Child Health Hospital of Hangzhou from March 2019 to August 2022 were selected and divided into study group (n=115) and control group (n=115) according to the odd and even number of treatment. The study group received tranexamic acid injection with water-light needle and hydroquinone cream. In the control group, tranexamic acid was injected with water light needle and asiaticoside ointment was applied. After the treatment, the effective rate, melasma area and severity index, dermatology life quality index, recurrence rate and incidence of adverse drug reactions were compared between the two groups. After the treatment, the total effective rate of the study group was 94.78 %, which was significantly higher than 80.87 % of the control group (p<0.05). The melasma area and severity index and dermatology life quality index scores of the study group were lower than those of the control group (p<0.05), and the recurrence rate and adverse drug reaction rate of the study group were lower than those of the control group (p<0.05). Tranexamic acid and hydroquinone cream with water light needle in the treatment of melasma has obvious curative effect, high safety, low recurrence rate and high patient satisfaction, significantly enhance the quality of life and it is worthy of drug promotion.