Efficacy and Safety of Topical Calcipotriol Plus Betamethasone Dipropionate Versus Topical Betamethasone Dipropionate Alone in Mild to Moderate Psoriasis

M Sindhuja,N S Muthiah

doi:10.9734/jpri/2021/v33i23a31406

Abstract

Psoriasis is one of the prototypic papulosquamous skin diseases characterized by erythematous papules or plaques. This disease is chronic in nature with a tendency to relapse. Betamethasone dipropionate binds to specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. The study duration was 6 weeks. A total of 60 study participants of both sexes diagnosed with mild to moderate psoriasis were included in the study. They were randomized into two groups. Group A – topical calcipotriol plus betamethasone treatment group consisting of 30 patients and Group B – topical betamethasone alone also consisting of 30 patients and a total of 28 patients in topical calcipotriol plus betamethasone treatment group and 28 patients in topical betamethasone group completed the study. A total of 98 patients were screened for this study, out of which 38 patients were excluded where 11 patients refused to participate and 27 patients didn’t meet the inclusion criteria of our study. These results shows that there is statistically significant percentage reduction in PASI score after 2 weeks (p=0.01) and 4weeks (p<0.001) of treatment in both groups. As a conclusion, the combination therapy of topical calcipotriol plus betamethasone provided a promising strategy for the treatment of mild to moderate psoriasis.

Highlights

Psoriasis is a common autoimmune skin disease is derived from Greek word “psora” which means “itch” [1]
The selected population of 60 patients was randomized to two groups and the treatment started as and when they reported to the hospital
One patient from calcipotriol plus betamethasone group requested to remove from the study during his 1st visit (2 weeks) and withdrew his consent

Summary

Introduction

Psoriasis is a common autoimmune skin disease is derived from Greek word “psora” which means “itch” [1]. It is characterized by round, circumscribed, dry, scaling plaques of varying sizes and covered by greyish white or silvery white scales, affecting approximately 2% of the population and leads to considerable impairment of the quality of life of the affected patients [1,2]. The most commonly affected sites are the scalp, tips of fingers and toes, palms, soles, umbilicus, gluteus, under the breasts and genitals, elbows, knees, shins and sacrum [3] Psoriasis affects both sexes and can occur at any age. The genetics of psoriasis are known to be complex, with ten or more susceptibility loci, and these probably interact with various environmental factors that act on the skin or immune system

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