Efficacy and safety of the injection of the traditional Chinese medicine salviae miltiorrhizae and ligustrazine hydrochloride for the treatment of perioperative period of fracture: A meta-analysis of randomized controlled trials.

Jialong Xie,Shichun Chen,Shaobo Ding

doi:10.1097/md.0000000000019777

Abstract

Background:The injection of the traditional Chinese patent medicine salviae miltiorrhizae and ligustrazine hydrochloride injection (SMLHI) has been widely used in treatment of various diseases such as angina pectoris or ischemic stroke in China. We aim to evaluate the efficacy and safety of SMLHI for the treatment of perioperative period of fracture.Methods:A systematic literature search was performed in seven medical databases from their inception until February 2019. 16 studies with randomized controlled trials, totaling 1589 patients, were included in this meta-analysis. The included studies were assessed by the cochrane risk of bias and analyzed by Review Manager 5.3 software.Results:The meta-analysis showed that SMLHI for the treatment of perioperative period of fracture was significantly better compared with the control group in terms of the total effective rate. The result showed that SMLHI could significantly reduce the risk of deep vein thrombosis and inflammatory cytokines. Furthermore, the result showed that SMLHI could significantly improve the coagulation function indexes such as prothrombin time, plasma fibrinogen and D-Dimer (P < .0001).Conclusions:This meta-analysis demonstrated that SMLHI may be more effective and safe for the treatment of perioperative period of fracture. However, further and higher quality randomized controlled trials are required to prove treatment outcome.

Highlights

Fracture has accounted for more than 50% of all the injuries with the increasing aging of country and the increasing of trafficEditor: Undurti N
The meta-analysis showed that salviae miltiorrhizae and ligustrazine hydrochloride injection (SMLHI) for the treatment of perioperative period of fracture was significantly better compared with the control group in terms of the total effective rate (OR = 6.10, 95%confidence interval (CI) = 2.37, 15.75, P = .0002) (Fig. 3)
The result showed that SMLHI could significantly improve the coagulation function indexes such as D-Dimer (SMD = -2.16, 95%CI = -3.13, -1.19, P < .0001), activation partial thromboplastin time (MD = 2.98, 95%CI = 0.64, 5.32, P = .01) and prothrombin time (MD = 0.79, 95%CI = 0.36, 1.23, P = .0003), compared with the control group (Table 2)

Summary

Introduction

Fracture has accounted for more than 50% of all the injuries with the increasing aging of country and the increasing of traffic. Das. JX and SC are equal contributors and co-first authors. The authors have no conflicts of interest to disclose. Data sharing not applicable to this article as no datasets were generated or analyzed during the current study. The injection of the traditional Chinese patent medicine salviae miltiorrhizae and ligustrazine hydrochloride injection (SMLHI) has been widely used in treatment of various diseases such as angina pectoris or ischemic stroke in China. We aim to evaluate the efficacy and safety of SMLHI for the treatment of perioperative period of fracture

Objectives

Methods

Results

Discussion

Conclusion