Abstract

Efficacy and safety of Thai herbal recipe in advanced hepatocellular carcinoma: A pilot, randomized, controlled clinical trial

Highlights

  • Hepatocellular carcinoma (HCC) is one of the leading causes of malignancies and cancer-related deaths worldwide, including Thailand

  • The three roots collected from Nong Bua Lamphu Province, northeast Thailand showed no contamination of any heavy metal, i.e., arsenic, lead, and cadmium

  • The primary objective of this study was to evaluate the efficacy and side effects of a herbal recipe which is commonly used for advanced HCC in the northeastern region of Thailand

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Summary

Introduction

Hepatocellular carcinoma (HCC) is one of the leading causes of malignancies and cancer-related deaths worldwide, including Thailand. The treatment protocols for this patient group include surgical resection, radio frequency ablation, and liver transplantation, and they require a multidisciplinary approach to ensure an optimal outcome. Those diagnosed with advanced disease usually have a poor prognosis, with a median survival of 7.9 months (Balogh et al, 2016). The oral tyrosine kinase inhibitor, sorafenib, is considered as the new standard treatment for advanced HCC to improve the treatment outcomes and prolong overall survival (Llovet et al, 2008). Many patients in Thailand cannot take this special drug due to the expensive drug cost

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