Efficacy and Safety of Silodosin, Prednisolone or Both for Spontaneous Passage of Lower UretericStones and Renal Colic Control

Abdulwahab Hussein,Akram Hassanin,Ahmed Mahmoud,Amr Hussein,Ahmed Ahmed

doi:10.21608/ejmr.2022.216584

Abstract

Efficacy and Safety of Silodosin, Prednisolone or Both for Spontaneous Passage of Lower UretericStones and Renal Colic Control

Highlights

Introduction and objectivesMedical expulsive therapy has become an established modality of treatment for lower ureteric stones and it involves using of different drugs that act on ureter by different mechanisms
The time for stone passage is supposed to be 2 weeks (7), but the patient may suffer from recurrent attacks of renal colic or UTIs, so decision of treatment depends on multiple factors like stone size, its location, severity of obstruction, anatomy of urinary system and patient preference
Stone formation and its passage in the ureter may lead to inflammation and edema in the mucosa of the ureter so it may interfere with passage of stones and worse patient condition, so using of anti-inflammatory and antiedematous treatment like corticosteroids “e.g. Methylprednisolone” supports a significant effect on distal ureteral stone expulsion. (15)

Summary

Introduction

Medical expulsive therapy has become an established modality of treatment for lower ureteric stones and it involves using of different drugs that act on ureter by different mechanisms. Results: Stone size has high statistical significance with stone passage, time of expulsion and analgesic requirement between group A and both group B and group C (p-value < 0.001). Medical expulsive therapy has become an established modality of treatment and it involves using of different drugs that act on ureter by different mechanisms. Stone formation and its passage in the ureter may lead to inflammation and edema in the mucosa of the ureter so it may interfere with passage of stones and worse patient condition (renal colic, UTIs), so using of anti-inflammatory and antiedematous treatment like corticosteroids “e.g. Methylprednisolone” supports a significant effect on distal ureteral stone expulsion. Stone formation and its passage in the ureter may lead to inflammation and edema in the mucosa of the ureter so it may interfere with passage of stones and worse patient condition (renal colic, UTIs), so using of anti-inflammatory and antiedematous treatment like corticosteroids “e.g. Methylprednisolone” supports a significant effect on distal ureteral stone expulsion. (15)

Objectives

Methods

Results

Conclusion