Abstract
''Efficacy and Safety of Polyacrylate Polyalcohol Co-polymer (Vantris) Injection Material in the Endoscopic Treatment of VUR in Children: 3 Years of Prospective Follow Up
Highlights
Vesicoureteral reflux (VUR) is the retrograde flow of urine from the bladder to the upper urinary tract
The outcomes of first voiding cystourethrogram (VCUG) done at 3 months after single injection of Vantris material, shows complete resolution of grade II VUR (10/10 refluxing renal unit (RRU)), 32/35 RRUs of grade III had no VUR and 23/25 RRUs with grade IV had no VUR
In total 65/70 RRUs had resolved VUR as shown in table [4], while those RRU who downgraded to grade I kept on conservative therapy for 3 months VCUG was done; 4 of them reached complete resolution of VUR and only 1 RRU required second injection
Summary
Vesicoureteral reflux (VUR) is the retrograde flow of urine from the bladder to the upper urinary tract. Vesicoureteral reflux is believed to be present in 1% or less of normal children, the incidence is likely to vary depending on the age of screening because VUR mostly resolved over time. Males and females are to have VUR after UTI, but males are more likely to have higher grade VUR [3]. Patients who have prenatally detected VUR have higher grade VUR than children detected after UTI. There is a genetic predisposition to VUR, with some studies suggesting an autosomal dominant inheritance with variable penetrance no specific genetic loci have been defined [7] These findings are dramatically illustrated by high incidence of reflux in siblings. The overall success rates which were reported by the different groups ranged between 68–92%, depending mainly on the VUR grade [17,18,19]
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