Abstract
Aim: This animal study aims to examine the efficacy and safety of poly-D,L-lactic acid (PDLLA) microspheres as subdermal fillers.
Highlights
Polylactic acid (PLA) was originally synthesized from α-hydroxy acids by French chemists in 1954
After injecting PDLLA filler into the dorsal subdermal tissues of Sprague Dawley (SD) rats, no significant skin color changes were observed in the injection sites compared with the untreated sites, and circular elevations were noted [Figure 1A-C]
The PDLLA filler mass was visually pale yellow compared with the subdermal tissues from the inner side after peeling off the muscle tissues [Figure 2A and B]
Summary
Polylactic acid (PLA) was originally synthesized from α-hydroxy acids by French chemists in 1954. This polymer has been used safely in resorbable suture materials, plates, and screws in orthopedic, neurologic, and craniofacial surgeries[1,2,3,4,5,6]. PLLA and PDLLA have been extensively studied and have shown promising results[8,9,10]. In 1999, injectable PLLA was approved for use in Europe (New-Fill; Biotech Industry SA, Luxembourg, Luxembourg). In August 2004, injectable PLLA (Sculptra; Dermik Laboratories, Bridgewater, NJ) was approved for the treatment of HIV-associated facial lipoatrophy in the United States[12]. In 2009, this approval was expanded to include cosmetic applications[13]
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