Efficacy and safety of local application of Vijaya oil in the management of Sandhivata with special reference to Osteoarthrosis: An open-labeled single-arm clinical trial

Abstract

Background: Osteoarthrosis is the second most common rheumatologic problem in India. Symptoms of Osteoarthrosis resemble Sandhivata in Ayurveda. Vijaya (cannabis sativa) oil manufactured by Bombay Hemp Company is used as a topical application in patients suffering from Sandhivata. Aim: To evaluate the efficacy & safety of local application of Vijaya oil in patients suffering from Sandhivata, with special reference to Osteoarthrosis. Materials and methods: Present clinical study was an open-label, single-arm study for the management of Sandhivata aged 30-75. The oil was applied locally on the affected site for 2 months. A total of 42 eligible patients suffering from symptomatic OA were enrolled, and 40 completed the study. Patients were assessed by clinical sign and symptom score for Sandhivata, Visual Analog Scale for Pain (VAS), WOMAC score for pain, stiffness, and physical function difficulty, Quality of life (QOL) score, Global assessment scale (GAS), and Overall disease severity (ODS). Statistical analysis was done by the Wilcoxon test. Results: The result was highly significant for all the subjective parameters. Conclusion: The study revealed that Vijaya oil significantly reduced pain, and stiffness, improved quality of life, and physical functions. It could be concluded that Vijaya oil can be a used as safe and effective drug of choice in patients suffering from Sandhivata.