Efficacy and safety of lansoprazole in the treatment of gastric ulcer

Abstract

Objective: To compare the efficacy and safety of lansoprazole 30 mg and omeprazole 20 mg in the treatment of benign gastric ulcer. Patients and methods: A multicentre, randomized, comparative, double-blind study was conducted in two parallel groups. Patients with a single gastric ulcer over 5 mm in diameter were included in the study. Efficacy was assessed by the ulcer healing rate on endoscopy and symptom relief. A total of 126 patients were included, 60 of whom received lansoprazole. At admission into the trial, the two groups were comparable for demographic data, tobacco and alcohol consumption, symptoms and ulcer size. Results: The cumulative healing rates by intent-to-treat analysis were 82 and 68% at 4 weeks and 93 and 82% at 8 weeks (P=0.04) for lansoprazole and omeprazole, respectively. By per protocol analysis, the healing rates were 88 and 82% at 4 weeks and 100 and 98% at 8 weeks for lansoprazole and omeprazole, respectively. The time to gastric pain relief was 6.6 days for lansoprazole and 11.0 days for omeprazole. The treatment was well tolerated in both groups. Conclusions: Lansoprazole was safe and effective in healing gastric ulcer with a trend towards faster pain relief compared with omeprazole.