Abstract
Background: Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. With the high incidence of asthma, there has been a surge in the use of complementary therapies, such as compound honey syrup in Traditional Persian Medicine, in the treatment of asthma. The aim of this study was to evaluate the efficacy and safety of Iranian poly herbal formulation (compound honey syrup) in the treatment of mild to moderÂate pediatric asthma. Materials and Methods: The study was a randomized clinical trial that was conducted on 80 patients with mild to moderate asthma assigned to two groups (n=40 for each group) for eight weeks. Control and experimental groups received classical treatment of asthma with fluticasone spray; in case of worsening of symptoms, salbutamol spray was used for short term. The experimental group also received compound honey syrup (the combinaÂtion of honey and an extract of the following five medicinal plants: ginger, cinnamon, safÂfron, cardamom, and galangal). Asthma Control Questionnaire (ACQ) items and total scores of ACQ were evaluated before and after treatment. Results: To this end, 72 patients completÂed this study. There was no significant difference between the experimental and the control groups in baseline data such as age, sex, body mass index, ACQ items, and ACQ scores. Total scores and all items of ACQ, with the exception of forced expiratory volume in one second (FEV1%), were significant between groups (P<0.05). No serious adverse effects were obÂserved in the two groups. Conclusions: The results of this study reveal that compound honey syrup can be a safe and effective complementary drug for the treatment of pediatric asthma [GMJ.2017;6(4):291-301] DOI: 10.22086/gmj.v6i3.884
Highlights
Asthma, as one of the major causes of chronic airway disease, has affected 334 million people in 2014 across the globe [1]
At the end of the 8 weeks of study, night symptoms, morning symptoms, activity limitation, shortness of breath, wheeze, use of SABA, and total scores of Asthma Control Questionnaire (ACQ) were significantly reduced in both groups, and all mentioned variables in the experimental group were significant (P
There was no significant difference in FEV1% between the two groups (P=0.43), and within the experimental and the control group; there was significant improvement
Summary
As one of the major causes of chronic airway disease, has affected 334 million people in 2014 across the globe [1]. From the prehistoric era to 637 AD, the annals of ancient Iran date back to about 10,000 years ago, with the development of medicinal science being remarkable Prominent medieval scientists, such as Razi (Rhazes; 865-925 AD), Ali Ebn Abbas (Haly Abbas; 949-982 AD), Ibn Sina (Avicenna; 980-1037 AD), and Jorjani (Sorsanus; 1042-1137 AD), significantly influenced the improvement of Iranian medical science. The use of Iranian poly herbal formulation (compound honey syrup) is one of the most common treatment for asthma in TPM [16, 17]. With the high incidence of asthma, there has been a surge in the use of complementary therapies, such as compound honey syrup in Traditional Persian Medicine, in the treatment of asthma. Conclusions: The results of this study reveal that compound honey syrup can be a safe and effective complementary drug for the treatment of pediatric asthma.
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