Efficacy and Safety of Dual-Drug-Eluting Stents for de Novo Coronary Lesions in South Korea-The Effect Trial.

Jung-Joon Cha,Tae Hoon Ahn,Jae Woong Choi,Dong-Kyu Jin,Seung Ho Hur,Do-Sun Lim,Cheol Ung Choi,Gi Chang Kim,Yun-Hyeong Cho,Seong Il Woo,Jang Ho Bae,Jong Seon Park,Seung Uk Lee

doi:10.3390/jcm10010069

Abstract

Background: Drug-eluting stents (DESs) are commonly used in percutaneous coronary intervention (PCI) procedures; however, complications including in-stent restenosis and stent thrombosis are significant challenges. The dual-DES is a stent that elutes two drugs to target various stages of the restenosis reaction. This study investigated the safety and efficacy of dual-DES in clinical practice. Methods: This study included 375 patients who underwent PCI with Cilotax™ or DXR™ dual-DESs at one of 13 centers in South Korea. The primary endpoint was target lesion failure (TLF) within 1 year. The secondary endpoints were cardiac death, myocardial infarction (MI), target lesion revascularization (TLR), and stent thrombosis. Results: The rates of TLF in dual-DESs (3.7%) were comparable to those reported in conventional DES. In addition, the DXR™ group had a significantly lower rate of TLF than the Cilotax™ group. In multivariate analysis, the DXR™ group had a lower risk of TLF (adjusted hazard ratio (HR) 0.30, 95% CI 0.09–0.92, p = 0.036) and MI (adjusted HR 0.16, 95% CI 0.03–0.82, p = 0.027) than the Cilotax™ group. Conclusion: Dual-DESs had similar clinical outcomes regarding efficacy and safety as conventional DES. Among the dual-DES, the DXR™ stent as a new generation dual-DES had more favorable clinical outcomes than the Cilotax™ stent.

Highlights

Drug-eluting stents (DESs) are commonly used for percutaneous coronary intervention (PCI) due to their lower restenosis rates than bare-metal stents (BMS) [1,2]
Intravascular ultrasound or other monitoring equipment was and DXRTM groups, with the exception of age, which was higher in the CilotaxTM group used, and glycoprotein IIb/IIIa inhibitor or anticoagulant therapy was administered
The CilotaxTM group had a higher rate of during the procedure according to the treatment standard of the medical institution

Summary

Introduction

Drug-eluting stents (DESs) are commonly used for percutaneous coronary intervention (PCI) due to their lower restenosis rates than bare-metal stents (BMS) [1,2]. Dual-DESs are stents that elute two drugs to target various stages of the restenosis reaction. In South Korea, two new dual-DESs, composed of paclitaxel and cilostazol, are currently used: the first-generation dual-DES CilotaxTM and the second-generation dualDES DXRTM. Drug-eluting stents (DESs) are commonly used in percutaneous coronary intervention (PCI) procedures; complications including in-stent restenosis and stent thrombosis are significant challenges. The dual-DES is a stent that elutes two drugs to target various stages of the restenosis reaction. Methods: This study included 375 patients who underwent PCI with CilotaxTM or DXRTM dual-DESs at one of 13 centers in South Korea. Among the dual-DES, the DXRTM stent as a new generation dual-DES had more favorable clinical outcomes than the CilotaxTM stent

Methods

Results

Discussion

Conclusion