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Abstract
Objective To investigate the efficacy and safety of domestic Oseltamivir granules in the treatment of influenza A in children. Methods The research subjects were the hospitalized patients with influenza A coming from the Department of Infectious Disease in Guangzhou Women and Children's Medical Center.from January and March, 2014 They were divided into 2 groups randomly.Patients in the treatment group received domestic Oseltamivir granules, while the patients in the control group received foreign Oseltamivir.Chi square test was performed to compare baseline characteristics and the difference in side effects.Paired t test was used to compare baseline characteristics and the difference in side effects. Results There were 44 cases in the study group, 27 cases were male(61.36%), 17 cases were female(38.64%), and the average age was (2.40±1.97) years old.There were 40 cases in the control group, 28 cases were male (70.00%), 12 cases were female(30.00%), and the average age was (2.99±3.19) years old.The maximum age was 6 years old.The age and gender were not significant (P>0.05) between 2 groups.The fever remission time was (14.67±9.37) h and (11.80±9.98) h in the treatment group and the control group, and there was no significant difference between 2 groups (P>0.05); the flu symptoms completely remission time was (62.50±25.03) h and (65.40±36.74) h in the treatment group and the control group, and there was no significant difference between 2 groups (P >0.05); the adverse reaction was not observed in the treatment group, but 1 case in the control group had cough, and without special treatment cough alleviated gradually; the close contacts in 2 groups did not develop influenza A. Conclusions The domestic Oseltamivir granules are as effective and safe as the foreign Oseltamivir.And the domestic Oseltamivir granules are the granular type, and therefore more suitable for children Key words: Influenza; Domestic Oseltamivir granule; Child; Randomized controlled trial
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