Abstract
Objective. To evaluate the efficacy and safety of docetaxel plus oxaliplatin and capecitabine (DOX) in the first line treatment of advanced gastric adenocarcinoma. Methods. A total of 37 patients were enrolled into this study, and they received DOX regimen (docetaxel 75 mg/m2 and oxaliplatin 130 mg/m2 intravenous infusion on day 1, and capecitabine 1000 mg/m2 orally twice daily on d1–14); treatment was repeated every 3 weeks. Results. All 37 patients were assessable for evaluation. The numbers of patients with complete response (CR), partial responses (PR), stable disease (SD), and progressive disease (PD) were 1, 10, 23, and 3, respectively. The objective response rate (ORR) was 29.7%, with the disease control rate (DCR) of 91.9%. Median progression-free survival (mPFS) and overall survival (mOS) were 197 days and 364 days, respectively. The most common grade 3/4 toxicities were hematological toxicities. The most common grade 3/4 nonhematological toxicities were fatigue, nausea, vomiting, anorexia, diarrhea, and hand-foot syndrome. Conclusion. The DOX regimen demonstrated a promising efficacy as the first line regimen in treating advanced gastric cancer patients with good performance status, the toxicities were tolerated and controllable. Large-scale clinical observation is necessary to get further evidence.
Highlights
Gastric cancer is the second most common cause of cancerrelated deaths worldwide
The main eligibility criteria included (1) age 18–75 yrs, (2) histologically proven gastric adenocarcinoma, (3) measurable and/or evaluable targeted lesion according to RECIST criteria, (4) good performance status with the Eastern Cooperative Oncology Group (ECOG) score of 0–2, (5) no prior chemotherapy, and (6) adequate hepatic, renal, and hematological function
The dosage of docetaxel was referred from TAX 325 trial, the dosages of oxaliplatin and capecitabine were referred from REAL-2 and ML17032 trials
Summary
Gastric cancer is the second most common cause of cancerrelated deaths worldwide. The outcome of advanced gastric cancer patients is poor, and the median survival time of untreated patients is less than 6 months [1]. A number of randomized clinical trials have established the role of chemotherapy in the treatment of patients with advanced gastric cancer. Compared with those in best support care (BSC) group, the median survival time in chemotherapy groups was longer (7.5–12 months versus 3–5 months). 5-fluorouracil plus cisplatin has been considered as the backbone doublet regimen. Anthracyclin is added to form triplet regimen, such as epirubicin, cisplatin, and continuous-infusion 5-FU (ECF)
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