Abstract

 
 
 
 Purpose: To investigate the effect and safety of a combination of Nifuratel tablets and Baofukang suppository in the treatment and recurrence of vaginitis in pregnant patients.
 Methods: A retrospective analysis was carried out on 100 in-patients admitted between February 2019 and April 2020. They were randomly assigned to control and study groups, with 50 in each group. The control group received Baofukang suppository treatment, whilst the study group was treated with Nifuratel tablets in addition to Baofukang suppository. The two groups were compared with regard to treatment effectiveness, incidence of adverse reactions, recurrence at 1, 2 and 3 months post-treatment; time taken for disappearance of clinical symptoms, and levels of inflammatory factors 1 week after treatment. Moreover, Mental Status Scale in Non-Psychiatric Settings (MSSNS) score, and Quality of Life Index (QLI) score were compared between the groups.
 Results: The study group out-performed the control group with respect to treatment effectiveness and QLI score (p < 0.05). Patients in the study group had significantly lower incidence of adverse reactions, degree of recurrence at 1, 2 and 3 months post-treatment, time taken for disappearance of clinical symptoms, expression levels of inflammatory factors, and MSSNS score, when compared to those in control group (p < 0.05).
 Conclusion: Combined use of Nifuratel tablets and Baofukang suppository in the treatment of pregnant patients with vaginitis leads to significant treatment efficacy and safety, and reduced recurrence and expression levels of inflammatory factors in patients.
 
 
 
Highlights
Vaginitis is a common complaint among pregnant women
The two groups were compared with respect to percentage treatment effectiveness, incidence of adverse reactions, recurrence at 1 month, 2 months and 3 months post-treatment; time taken for disappearance of clinical symptoms, levels of inflammatory factors 1 week after treatment, Mental Status Scale in Non-Psychiatric Settings (MSSNS) score and Quality of Life Index (QLI) score
The study compared the two groups in terms of % treatment effectiveness, incidence of adverse reactions, recurrence at 1 month, 2 months and 3 months post-treatment; time taken for disappearance of clinical symptoms, expression levels of inflammatory factors 1 week after treatment, MSSNS score and QLI score
Summary
Vaginitis is a common complaint among pregnant women. The main clinical manifestations are vaginal pain and itching, and abnormal secretion of body fluids. Vaginitis, which may be due to fungal and bacterial infections, is classified into bacterial vaginitis, mycotic vaginitis and trichomoniasis vaginitis [1,2,3]. It probably occurs in pregnant women due to changes in hormonal. Some pregnant women may ignore the importance of timely treatment of vaginitis. This may affect the delivery and health of the fetus. Nifuratel is a drug widely used for treating bacterial vaginosis, trichomoniasis vaginitis and other vaginal diseases due to its desirable effect [7,8]. The two groups were compared with respect to percentage treatment effectiveness, incidence of adverse reactions, recurrence at 1 month, 2 months and 3 months post-treatment; time taken for disappearance of clinical symptoms, levels of inflammatory factors 1 week after treatment, MSSNS score and QLI score
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