Efficacy and Safety of Combination of Mometasone Furoate 0.1% Cream and Adapalene 0.1% Gel in Alopecia Areata

Abstract

AbstracBackground: Alopecia areata (AA) is an autoimmune disease characterized by non‐cicatricial hair loss. No definitive therapy currently exists for AA. Despite use of topical corticosteroids in AA, the success of these agents is controversial. Thus, the aim of this study was to evaluate the efficacy of the mometasone furoate plus adapalene in the treatment of AA.Material and Methods: A study on alopecia areata patients from the outpatient clinic of Dermatology, Venereology Department, Faculty of Medicine of Zagazig University in the period from June 2018 to February 2019. This study included 40 patients of alopecia areata of both sexes with chronic disease . Patients were treated with combination of Adapalene 0.1 gel and mometasone furoate 0.01 cream. Patients used this combination by themselves at home for 6 months. The response was assessed by the “SALT”. Patients were assessed every 2 weeks for 6 months. Side effects were recorded.Results: We found that 35% patients showed 100% response, 5% patient showed 75% response and 60% patients showed no hair regrowth. As regarding side effects, 85% of the patients showed side effects, but no patient was lost. As regarding side effects, 85% of the patients showed side effects, in the form of erythema in 60% of cases, irritation in 85% of cases and telangiectasia in 25% of cases.Conclusion: Combined use of adapalene gel and mometasone furoate cream is favorable modality of AA treatment only for mild cases. It can be applied easily by the patient at home. Side effects were mild.