Abstract
Objective: study of the prolonged effects of a three-month course of therapy with citicoline, carried out three times for three years, to prevent the progression of cognitive deficit in 1st-degree relatives of patients with Alzheimer’s disease (AD).Study participants: the study involved first-degree relatives of patients with an established diagnosis of AD.Study design: an openlabel comparative three-year prospective study of the dynamics of cognitive status in two groups of relatives, one of whom received citicoline therapy (1st group), and the other did not (2nd group). The 1st group made up 48 relatives (11 — with mild cognitive impairment syndrome and 37 — with signs of minimal cognitive dysfunction). 32 relatives who had not received drug treatment for 3 years (8 of them had objectively confirmed signs of minimal cognitive dysfunction, in 24 people — cognitive functioning corresponded to the normal aging) were included to 2nd group. The groups did not have significant differences in demographic characteristics and distribution of the ApoE4(+) genotype carriers.Methods: clinical and psychological, psychometric, ApoE genotyping, statistical.Results: in the therapeutic group, a significant improvement in the cognitive status was found in 75.0% of the treated relatives with cognitive disfunction on most scales and tests, with the exception of the clock drawing test. In the group of relatives who did not receive drug therapy, there was a significant deterioration of cognitive functioning — in 2 cases with the formation of mild cognitive impairment syndrome, in 21 cases — with the appearance of minimal cognitive signs.Conclusion: the results of a three-year preventive course of citicoline therapy showed a significant positive effect of the drug on the cognitive status of the 1st degree relatives of AD patients who had signs of cognitive impairment that did not reach the level of dementia.
Highlights
The 1st group made up 48 relatives (11 — with mild cognitive impairment syndrome and 37 — with signs of minimal cognitive dysfunction). 32 relatives who had not received drug treatment for 3 years (8 of them had objectively confirmed signs of minimal cognitive dysfunction, in 24 people — cognitive functioning corresponded to the normal aging) were included to 2nd group
Results: in the therapeutic group, a significant improvement in the cognitive status was found in 75.0%
Conclusion: the results of a three-year preventive course of citicoline therapy showed a significant positive effect of the drug on the cognitive status of the 1st degree relatives of Alzheimer’s disease (AD) patients who had signs of cognitive impairment that did not reach the level of dementia
Summary
Резюме Цель исследования: изучение пролонгированных эффектов трехмесячных курсов терапии препаратом цитиколин, проведенной трижды в течение трех лет и направленной на профилактику прогрессирования когнитивного дефицита у родствен- 33 ников 1-й степени родства пациентов с болезнью Альцгеймера (БА). В 1-ю группу вошли 48 человек (11 с синдромом мягкого когнитивного снижения и 37 с признаками минимальной когнитивной дисфункции). Результаты: в терапевтической группе установлено значимое улучшение когнитивного статуса как у пролеченных родственников с синдромом мягкого когнитивного снижения, так и у лиц с минимальной когнитивной дисфункцией. В группе родственников, не получавших медикаментозную терапию, установлено значимое ухудшение по всем показателям когнитивного функционирования — в 2 случаях с формированием синдрома мягкого когнитивного снижения, в 21 случае — с появлением признаков минимальной когнитивной дисфункции. Эффективность и безопасность цитиколина в профилактике прогрессирования когнитивного дефицита у родственников 1-й степени родства пациентов с болезнью Альцгеймера: проспективное исследование.
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