Abstract

Efficacy and safety of azoximer bromide (Polyoxidonium) in children aged from 1 to 12 years with ARI: The results of a multicenter prospective, randomized, double-blind, placebo-controlled, parallel-group study

Highlights

  • Acute respiratory viral infections (ARVI) remain one of the most relevant problems due to the high specific weight in the infectious pathology, the risk of severe complications

  • In connection with the above mentioned, it is relevant to search for methods to facilitate the course of ARVI and reduce the complications probability

  • Azoximer bromide (Polyoxidonium®), which has a complex action is of interest: immunomodulatory, detoxifying and anti-inflammatory effects

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Summary

Introduction

Acute respiratory viral infections (ARVI) remain one of the most relevant problems due to the high specific weight in the infectious pathology, the risk of severe complications. Children under 14 are significantly more likely to have ARVI than adults [1]. In connection with the above mentioned, it is relevant to search for methods to facilitate the course of ARVI and reduce the complications probability. Azoximer bromide (Polyoxidonium®), which has a complex action is of interest: immunomodulatory, detoxifying and anti-inflammatory effects. An important mechanism among the effects of azoximer bromide is the activation of non-specific factors of mucous membrane protection. The main mechanism of the immunomodulatory action of bromide azoximer is direct action on phagocytic cells and natural killers, as well as stimulation of antibody formation and interferon-alpha and

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