Efficacy and Safety of Autologous Serum Eye Drops in Treatment of Severe Dry Eye

Abstract

* Deptt of Ophthalmology. V.C.S.G.G.M.S.&R.I., Srinagar Garhwal, Uttarakhand, India. Abstract: Aim: To evaluate the efficacy and safety of autologous serum eye drops in treatment of severe dry eye. Material and methods: Twenty six eyes of thirteen severe dry eye patients were enrolled in this study. All patients were refractory to treatment with conventional artificial tears. Autologous serum eye drops were applied eight times a day per eye. Patients were evaluated subjectively and objectively with Schirmer's test, TBUT, Fluorescein stain at start of treatment, at two weeks, and six weeks after start of treatment. Results: Clinically and statistically significant improvement was seen both objectively and subjectively in patients of severe dry eye treated with autologous serum. Conclusion: Autologous serum eyedrops were found effective and safe in treatment of severe dry eye disease, as evidenced by improvement in subjective assessment of symptoms, Schirmer's score, tear film break-up time