Abstract

Porcine cysticercosis, an infection caused by Taenia solium metacestodes, is continuously being reported in low-income countries of Latin America, Asia, and sub-Saharan Africa. The disease was declared eradicable by the International Task Force for Diseases Eradication (ITFDE) in 1993, and it is listed among the 17 WHO Neglected Tropical Diseases and Neglected Zoonoses that are potentially eradicable. In view of that, WHO has proposed a step-wise approach to its elimination, including chemotherapy of infected pigs. Different drugs have been tested on porcine cysticercosis with varying efficacies. These include flubendazole, fenbendazole, albendazole, albendazole sulphoxide, oxfendazole, praziquantel, and nitazoxanide. This review summarises available information on the efficacies and adverse effects shown by these drugs in pigs. Oxfendazole has shown to be effective for the control of porcine cysticercosis; however, it needs to be integrated with other control approaches. There is a need for standardised guidelines for evaluating the efficacy of anthelmintics against porcine cysticercosis, and more efficacy studies are needed since the conclusions so far are based on a limited number of studies using few infected pigs.

Highlights

  • Making safe and evidence-based recommendations for porcine cysticercosis treatment requires adequate information on the efficacy and safety of the anthelmintics to be used [1]

  • This work focuses on evaluating the efficacy and safety of flubendazole, fenbendazole, albendazole, albendazole sulphoxide, oxfendazole, praziquantel, and nitazoxanide anthelmintics, which have been tested for treatment of porcine cysticercosis

  • The results from the two intervention studies showed that OFZ treatment was effective to control porcine cysticercosis; it needs to be integrated with other control approaches

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Summary

Introduction

Making safe and evidence-based recommendations for porcine cysticercosis treatment requires adequate information on the efficacy and safety of the anthelmintics to be used [1]. Seven anthelmintics have been evaluated in treatment of porcine cysticercosis employing naturally infected pigs [4]. This work focuses on evaluating the efficacy and safety of flubendazole, fenbendazole, albendazole, albendazole sulphoxide, oxfendazole, praziquantel, and nitazoxanide anthelmintics, which have been tested for treatment of porcine cysticercosis. The drug is registered for use in pigs for control of helminth infections other than T. solium cysticercosis with doses between 1.6–4 mg/kg [5]. Efforts to control porcine cysticercosis evaluated the effect of FLU in two treatment trials.

Effect on BC
Adverse effects
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