Abstract
Background: Melasma is a common hyperpigmentation disorder, characterized by light-to-dark brown patches, usually distributed on sun-exposed areas of the body. The objective of this study was to evaluate the efficacy and tolerability of an oral nutritional supplement containing Pinus pinaster and Grape seed extract, vitamins and minerals, used concomitantly with a high SPF sunscreen in 30 women with mild-to-moderate facial melasma. Methods: Efficacy was assessed by measurement of the Melasma Area and Severity Index (MASI), instrumental analysis of the lesions (Mexameter®, VISIA®)) and Patient’s and Physician’s Global Assessment (PGA). Results: The MASI score decreased significantly compared with baseline at days 28, 56, and 84. Mexameter® analysis showed a significant decrease of ∆M (difference in the melanin index between melasma and adjacent area). VISIA® results also showed a reduction in the number and areas of UV pigmented spots and in the areas of melasma overtime. Both the Patient’s and Physician’s Global Assessment showed that the product led to an improvement of the lesions in terms of depigmentation and had positive cosmetic features without adverse events. Conclusion: The oral supplement subject of this study in combination with high SPF sunscreen was effective and well-tolerated for treatment of mild to moderate facial melasma.
Highlights
Melasma is a common chronic acquired hyperpigmentation disorder of the skin, characterized by light-to-dark brown patches or macules with symmetrical disposition and irregular borders
Melasma is a common request for dermatological care and, due to its effect on facial appearance, the disease can be a source of embarrassment for subjects, negatively impacting their quality of life [3]
As shown by several studies, the aetiology of the disorder is not limited to melanocyte malfunction [1]
Summary
Melasma is a common chronic acquired hyperpigmentation disorder of the skin, characterized by light-to-dark brown patches or macules with symmetrical disposition and irregular borders It is usually present on sun-exposed areas of the body, the regions of the face that are rich in sebaceous glands [1], it can appear in other body areas such as forearms and neck [2]. Melasma is a common request for dermatological care and, due to its effect on facial appearance, the disease can be a source of embarrassment for subjects, negatively impacting their quality of life [3] The occurrence of this disorder has been strongly associated with melanocyte malfunction leading to overproduction of melanin, the naturally occurring pigment in humans responsible for skin, hair. Conclusion: The oral supplement subject of this study in combination with high SPF sunscreen was effective and well-tolerated for treatment of mild to moderate facial melasma
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