Abstract
Introduction: Bacterial and/ or fungal infection of the middle or external ear can be painful and sometimes the infection can be of mixed nature i.e. caused due to both bacteria and fungi. The combination of antibiotics and antifungals can be used for the treatment of mixed ear infections, along with it, anti-inflammatory agent and anaesthetics can be combined to relieve the discomfort caused by the infection. This study was conducted to test the efficacy and safety for the combination of Neomycin, Beclomethasone, Clotrimazole and Lignocaine for the treatment of middle or external ear infection.
 Method: Of enrolled 200, 177 patients completed the study. Efficacy was evaluated by symptom score (SS) scale which was an eleven-point scale ranging from 0 to 10 where 0 was no symptom to 10 was the maximum tolerated symptoms. All patients were asked to report SS on SS scale for ear pain, ear discharge and ear itching on day 1, 3 and 5. Safety assessment was made by analysing the adverse events reported by the patient.
 Results: SS of ear pain was reduced from 6.158 at baseline visit to 3.050 at day 3 to 0.468 at day 5. SS of ear discharge reduced from 6.175 at baseline to 2.768 at day 3 to 0.491 at day 5. SS of ear itching reduced from 4.694 at baseline to 1.604 at day 3 to 0.299 at day 5.
 Conclusion: The investigational product was found to be efficacious and safe for the treatment of otitis media and externa.
Highlights
Bacterial and/ or fungal infection of the middle or external ear can be painful and sometimes the infection can be of mixed nature i.e. caused due to both bacteria and fungi
Subtypes of ear infection according to their location are otitis externa, otitis media and otitis interna
For the complete medical management of otitis media and externa the combination of antifungal, antibacterial, local anaesthetic and antiinflammatory agent can be used.[3]. So according to the above statement, the combination of Neomycin, Beclomethasone, Clotrimazole and Lignocaine can be used for the medical management of otitis media and externa
Summary
Bacterial and/ or fungal infection of the middle or external ear can be painful and sometimes the infection can be of mixed nature i.e. caused due to both bacteria and fungi. Ear infection and inflammation is known as otitis is commonly caused by bacteria as well as fungi. Bacteria including but not limited to Staphylococcus aureus, Plasmodium aeruginosa and anaerobic bacteria are the most common infectious aetiologies, followed by fungi and mycobacteria.[1,2] Otitis media is a category of infective and inflammatory disorders that affects the middle ear. Externa and media are normally caused due to bacteria or fungi but sometimes it is caused due to both bacteria and fungi which is called as mixed ear infections. Mixed ear infections are generally treated with the topical treatment of combination of antibiotic and antifungal agents.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
