Abstract

Objective To investigate the efficacy and of amisulpride and sulpiride on treatment of patients with first-episode schizophrenia and its effect on patients' quality of life.Methods Ninetyfour patients with first-episode schizophrenia were randomly divided into sulpride group and amisulpride group.The treatment course was 8 weeks.Treatment efficacy and tolerability was evaluated using positive and negative syndrome scale(PANSS) and the treatment emergent symptom scale (TESS) at baseline and 2,4,8 weeks after treatment,respectively.Quality of life was evaluated using generic quality of life inventory-74(GQOLI-74) before treatment and 8 weeks after treatment.Results There were signiticant differences in the scores of PANSS before and after treatment in both groups(P ＜0.01).But there was no significant difference in PANSS scores between the two groups after treatment(P ＞ 0.05).There were significant differences in total score of GQOLI-74 and quality of physical health,psychological life and social function between the two groups (P ＜ 0.05 or ＜ 0.01),and amisulpride group was superior to sulpride group (P ＜ 0.05 or ＜ 0.01).Conclusions Amisulpride is as effective as sulpiride and is superior to sulpride in increasing quality of life in treatment of first-episode schizophrenia,and it has high safety and good compliance. Key words: First-episode schizophrenia; Amisulpride ; Sulpiride ; Efficacy ; Quality of life

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