Abstract
Objective To analyze the efficacy of androgen deprivation therapy (ADT) combined with radiation therapy (also known as radiotherapy) for prostate cancer. Methods The clinical data of 94 prostate cancer patients treated in the Oncology Department of Xiangzhou People's Hospital from January 2017 to January 2018 were retrospectively analyzed, and the patients were divided into the combined group and the reference group according to their admission order, with 47 cases each. The patients in the reference group only received the radiotherapy, and on this basis, those in the combined group accepted ADT, so as to evaluate the efficacy of different treatment methods by comparing the patients' serum total prostate-specific antigen (T-PSA), vascular endothelial growth factor (VEGF), and other indicators and analyze the relevant factors affecting patients' prognosis by Cox single-factor and multi-factor regression models. Results Compared with the reference group after treatment, the patients in the combined group obtained significantly lower T-PSA and VEGF levels (P < 0.001), significantly higher objective remission rate and disease control rate (P < 0.05), and remarkably longer modified progression-free survival (mPFS) and overall survival (OS) (P < 0.001), and after the multi-factor research, it was found that the Gleason score of 8–10, positive lymphatic metastasis, and single radiotherapy were the factors affecting the clinical prognosis of prostate cancer. Conclusion Combining ADT with radiotherapy ensures a better survival benefit for prostate cancer patients and has a fairly well efficacy. Further study will be conducive to establishing a better solution for such patients.
Highlights
ObjectiveTo analyze the efficacy of androgen deprivation therapy (ADT) combined with radiation therapy ( known as radiotherapy) for prostate cancer
Authoritative survey data show [1] that the incidence of prostate cancer reaches the 5th place among malignant tumors, becoming one of the important diseases endangering the male population. e tumor has an insidious onset and slow growth and will trigger dysuria, interruption of urinary stream, hematuria, and other symptoms once it causes swelling of the prostate, resulting in high deterioration, difficulty in treatment, and poor clinical prognosis and seriously affecting the physical and psychological functions of patients
A control study was carried out to explore the efficacy and prognostic factors of the combined therapy for prostate cancer patients, with the results reported as follows
Summary
To analyze the efficacy of androgen deprivation therapy (ADT) combined with radiation therapy ( known as radiotherapy) for prostate cancer. E patients in the reference group only received the radiotherapy, and on this basis, those in the combined group accepted ADT, so as to evaluate the efficacy of different treatment methods by comparing the patients’ serum total prostate-specific antigen (T-PSA), vascular endothelial growth factor (VEGF), and other indicators and analyze the relevant factors affecting patients’ prognosis by Cox single-factor and multi-factor regression models. Compared with the reference group after treatment, the patients in the combined group obtained significantly lower T-PSA and VEGF levels (P < 0.001), significantly higher objective remission rate and disease control rate (P < 0.05), and remarkably longer modified progression-free survival (mPFS) and overall survival (OS) (P < 0.001), and after the multi-factor research, it was found that the Gleason score of 8–10, positive lymphatic metastasis, and single radiotherapy were the factors affecting the clinical prognosis of prostate cancer. Further study will be conducive to establishing a better solution for such patients
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