Abstract
Traditional medicinal plants have been cultivated to treat various human illnesses and avert numerous infectious diseases. They display an extensive range of beneficial pharmacological and health effects for humans. These plants generally synthesize a diverse range of bioactive compounds which have been established to be potent antimicrobial agents against a wide range of pathogenic organisms. Various research studies have demonstrated the antimicrobial activity of traditional plants scientifically or experimentally measured with reports on pathogenic microorganisms resistant to antimicrobials. The antimicrobial activity of medicinal plants or their bioactive compounds arising from several functional activities may be capable of inhibiting virulence factors as well as targeting microbial cells. Some bioactive compounds derived from traditional plants manifest the ability to reverse antibiotic resistance and improve synergetic action with current antibiotic agents. Therefore, the advancement of bioactive-based pharmacological agents can be an auspicious method for treating antibiotic-resistant infections. This review considers the functional and molecular roles of medicinal plants and their bioactive compounds, focusing typically on their antimicrobial activities against clinically important pathogens.
Highlights
The incidence of microbial infectious diseases and their hitches consistently elevates, mostly due to microbial drug resistance to presently offered antimicrobial agents [1]
These bioactive compounds binding to the β subunit of gyrase and the corresponding blockage of the ATP binding pocket eventually contribute to the antimicrobial activity
Various investigations on the pharmacognostics and kinetics of medicinal plants have shown that crude extracts and plant-derived bioactive compounds may enhance the effects of traditional antimicrobials, which may be cost-effective, have fewer side effects, and improve the quality of treatment
Summary
The incidence of microbial infectious diseases and their hitches consistently elevates, mostly due to microbial drug resistance to presently offered antimicrobial agents [1] These multidrug-resistant microbes cause various infections globally and are connected with greater levels of morbidity and mortality [2]. Plant-derived compounds are a group of secondary metabolites that are used to treat chronic as well as infectious diseases These traditional medicinal plants or active compounds remain included as part of the habitual treatment of various maladies [9]. These compounds could have other target sites than conventional antimicrobials as well as diverse mechanisms of action against pathogenic microbes.
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