Efficacy and Mechanism of Butylphthalide Combined with Atorvastatin Calcium Tablets in the Diagnosis of Cerebral Infarction Using Iodol/Fe3O4 Nanometric Contrast Agent

Abstract

To determine serum proteolytic activity, NO (nitric oxide) levels, TAC (total antioxidant capacity), and TOS (total oxidant status) in acute hemorrhagic stroke, the in vivo oxidative stress response mechanism of atorvastatin was studied in a rat model with cerebral infarction. All patient contrast agents are Iodol/Fe₃O₄ nanometric contrast agents. Serum prolinease activity, catalase activity, NO levels, TAC, and TOS were spectrophotometrically determined and the OSI (oxidative stress index) calculated. In this study, the serum TAC level and catalase activity with acute hemorrhagic stroke were significantly lower than in the control group (each P = 0.001), while the level of NO, TOS, OSI, and protease were significantly higher than in the control group (P = 0.01). When patients were classified for acute hemorrhagic stroke by gender, there was no difference in serum prolinease activity, meanwhile, NO, TAC, and TOS levels, and OSI differed between men and women (as mentioned with details acknowledged by all, P = 0.05). The results of this study indicate that compared with the control group, elevated oxidative stress levels, decreased antioxidants levels, and elevated prolinease activity are correlated with acute hemorrhagic stroke. Additionally, further research is needed to elucidate the mechanisms of oxidative stress with acute hemorrhagic stroke.